Related topics: stem cells · cells · arthritis · osteoarthritis

Scientists discover a new mechanism to generate cartilage cells

As any weekend warrior understands, cartilage injuries to joints such as knees, shoulders, and hips can prove extremely painful and debilitating. In addition, conditions that cause cartilage degeneration, like arthritis and ...

Soft but tough: Biohybrid material performs like cartilage

Producing biomaterials that match the performance of cartilage and tendons has been an elusive goal for scientists, but a new material created at Cornell demonstrates a promising new approach to mimicking natural tissue.

Injectable stem cell assembly for cartilage regeneration

A study led by Prof. Qiuyu Zhang (Northwestern Polytechnical University), Prof. Ki-Bum Lee (Rutgers University), and Prof. Liang Kong (School of Stomatology, The Fourth Military Medical University) has established an injectable ...

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Cartilage

Cartilage is a type of dense connective tissue existing within many joints. It is composed of specialized cells called chondrocytes that produce a large amount of extracellular matrix composed of collagen fibers, abundant ground substance rich in proteoglycan, and elastin fibers. Cartilage is classified in three types, elastic cartilage, hyaline cartilage and fibrocartilage, which differ in the relative amounts of these three main components.

Cartilage is found in many areas in the body, including the articular surface of the bones, the rib cage, the ear, the nose, the bronchial tubes and the intervertebral discs. Its mechanical properties are intermediate between bone and dense connective tissue like tendon.

Unlike other connective tissues, cartilage does not contain blood vessels. The chondrocytes are fed by diffusion, helped by the pumping action generated by compression of the articular cartilage or flexion of the elastic cartilage. Thus, compared to other connective tissues, cartilage grows and repairs more slowly.

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