Related topics: cancer · cancer cells

Can we cure cancer by finding out how two proteins interact?

In a paper published in the Journal of Biological Chemistry, Dr. Özdemir has studied two protein families named Rho GTPases and IQGAPs, which are known to play an important role in cancer metastasis. These two "suspicious" ...

Engineer develops model to predict behavior of cell clusters

An engineer at Washington University in St. Louis discovered a model in which the mechanics of the cells' environment can predict their movement, a finding that ultimately could mean confining cell transition in tumors and ...

Engineered human colon model could aid in cancer research

Genetic mutations are a major cause of cancer, and tracking the role of each gene in cancer pathogenesis has long been an important tool in the fight against a disease that is expected to kill more than 1.6 million people ...

Light used to measure the 'big stretch' in spider silk proteins

While working to improve a tool that measures the pushes and pulls sensed by proteins in living cells, biophysicists at Johns Hopkins say they've discovered one reason spiders' silk is so elastic: Pieces of the silk's protein ...

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Metastasis

Metastasis (Greek: displacement, μετά=next + στάσις=placement, plural: metastases), or Metastatic disease, sometimes abbreviated mets, is the spread of a disease from one organ or part to another non-adjacent organ or part. Only malignant tumor cells and infections have the established capacity to metastasize; however, this is recently reconsidered by new research.

Cancer cells can break away, leak, or spill from a primary tumor, enter lymphatic and blood vessels, circulate through the bloodstream, and settle down to grow within normal tissues elsewhere in the body. Metastasis is one of three hallmarks of malignancy (contrast benign tumors). Most tumors and other neoplasms can metastasize, although in varying degrees (e.g., glioma and basal cell carcinoma rarely metastasize).

When tumor cells metastasize, the new tumor is called a secondary or metastatic tumor, and its cells are like those in the original tumor. This means, for example, that, if breast cancer metastasizes to the lungs, the secondary tumor is made up of abnormal breast cells, not of abnormal lung cells. The tumor in the lung is then called metastatic breast cancer, not lung cancer.

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