High-resolution mapping method for G4 DNA structures developed

While investigating the unusual G quadruplex DNA structure (G4), the Simon Elsässer group has developed a more accurate method for mapping these structures in the genome. G4 CUT&Tag revealed numerous G4s in the human and ...

Innovation massively expands view into workings of single cells

Researchers have devised a way to multiply by more than ten-fold the accessible details of gene activity in individual cells. It's a big leap in the effort to understand cancer development, brain function, immunity and other ...

Uncovering epigenetic mechanisms underlying cancer development

Northwestern Medicine studies published in Nature Cell Biology and Molecular Cell are improving the understanding of epigenetic mechanisms in cancer development and progression, as well as pinpointing genes that drive the ...

Cellular stress causes cancer cell chemoresistance

There is a broad range of mechanisms associated with chemoresistance, many of which to date are only poorly understood. The so-called cellular stress response—a set of genetic programs that enable the cells to survive under ...

Women firefighters face high exposure to toxic PFAS chemicals

San Francisco's women firefighters are exposed to higher levels of certain toxic PFAS chemicals than women working in downtown San Francisco offices, shows a new study led by researchers at the University of California, Berkeley, ...

Cells protect themselves against stress by keeping together

Cell-to-cell contacts are necessary for the survival of human cells under protein-damaging conditions and stress. This was one of the conclusions made by a research team working under the leadership of Lea Sistonen, Professor ...

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