UC Berkeley scientists have discovered simple CRISPR systems similar to CRISPR-Cas9—a gene-editing tool that has revolutionized biology—in previously unexplored bacteria that have eluded efforts to grow them in the laboratory.
CRISPR systems have been a hot research topic since they were shown to have utility as genetic engineering tools in 2012. And they're often explained in a way that most folks can understand. But those explanations often overlook ...
CRISPR-Cas systems are widely heralded as a new generation of genetic tools. But development of these tools requires researchers to identify the protospacer-adjacent motifs (PAMs) that unlock each system's functionality. ...
A new review highlights the diverse ways in which genetic-based defense systems found in bacteria can be harnessed to manipulate the microbes for various clinical and research applications. The systems, called CRISPR-Cas ...
Researchers from North Carolina State University and the University of North Carolina at Chapel Hill have for the first time created and used a nanoscale vehicle made of DNA to deliver a CRISPR-Cas9 gene-editing tool into ...
In a study that twists nature's arm to gain clues into the varied functions of the bacterial genome, North Carolina State University researchers utilize a precision scalpel to excise target genomic regions that are expendable. ...
A great deal of public attention in the past couple of years has been showered on complexes of bacterial proteins known as "CRISPR-Cas" for their potential use as a tool for editing DNA. Now, researchers with the Lawrence ...
Massachusetts General Hospital (MGH) investigators have developed a method of detecting, across the entire genome of human cells, unwanted DNA breaks induced by use of the popular gene-editing tools called CRISPR-Cas RNA-guided ...
Customized genome editing – the ability to edit desired DNA sequences to add, delete, activate or suppress specific genes – has major potential for application in medicine, biotechnology, food and agriculture.
Bacteria's memories of hostile viruses are stronger than thought. Even when the intruders change their DNA sequence, the immune system of bacteria can recognise these and subsequently destroy them. That is the conclusion ...
Dec 23, 2016
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