Related topics: brain · children · nerve cells · genes · brain regions

Modern humans generate more brain neurons than Neandertals

The question of what makes modern humans unique has long been a driving force for researchers. Comparisons with our closest relatives, the Neandertals, therefore provide fascinating insights. The increase in brain size, and ...

New technique reveals genes underlying human evolution

One of the best ways to study human evolution is by comparing us with nonhuman species that, evolutionarily speaking, are closely related to us. That closeness can help scientists narrow down precisely what makes us human, ...

Monkey skull study suggests brain evolved in spurts

(Phys.org)—A small team of researchers from Brazil and Argentina has found via skull analysis and modeling that a kind of new-world monkey appears to have undergone changes in individual parts of its brain during evolutionary ...

Evolving a bigger brain with human DNA

The size of the human brain expanded dramatically during the course of evolution, imparting us with unique capabilities to use abstract language and do complex math. But how did the human brain get larger than that of our ...

Fluctuating environment may have driven human evolution

A series of rapid environmental changes in East Africa roughly 2 million years ago may be responsible for driving human evolution, according to researchers at Penn State and Rutgers University.

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Neural development

The study of neural development draws on both neuroscience and developmental biology to describe the cellular and molecular mechanisms by which complex nervous systems emerge during embryonic development and throughout life.

Some landmarks of embryonic neural development include the birth and differentiation of neurons from stem cell precursors, the migration of immature neurons from their birthplaces in the embryo to their final positions, outgrowth of axons from neurons and guidance of the motile growth cone through the embryo towards postsynaptic partners, the generation of synapses between these axons and their postsynaptic partners, and finally the lifelong changes in synapses which are thought to underlie learning and memory.

Typically, these neurodevelopmental processes can be broadly divided into two classes: activity-independent mechanisms and activity-dependent mechanisms. Activity-independent mechanisms are generally believed to occur as hardwired processes determined by genetic programs played out within individual neurons. These include differentiation, migration and axon guidance to their initial target areas. These processes are thought of as being independent of neural activity and sensory experience. Once axons reach their target areas, activity-dependent mechanisms come into play. Neural activity and sensory experience will mediate formation of new synapses, as well as synaptic plasticity, which will be responsible for refinement of the nascent neural circuits.

Developmental neuroscience uses a variety of animal models including mice Mus musculus , the fruit fly Drosophila melanogaster , the zebrafish Danio rerio, Xenopus laevis tadpoles and the worm Caenorhabditis elegans, among others.

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