Embryo blood cells are stem cell–independent

The fetal liver is the major hematopoietic organ during the embryonic stage. It is generally believed that hematopoietic hierarchy in the fetal liver is established through the differentiation of fetal hematopoietic stem ...

Nanoparticle 'backpacks' restore damaged stem cells

Within a newborn's umbilical cord lie potentially life-saving stem cells that can be used to fight diseases like lymphoma and leukemia. That is why many new parents elect to store ("bank") their infant's stem cell-rich umbilical ...

A fine-tuned gene editor that minimizes adverse consequences

The molecular tool CRISPR-Cas9 can be used to treat inherited blood disorders, but this may cause unintended genetic alterations. A team led by MDC researchers Klaus Rajewsky and Van Trung Chu has now presented an approach ...

Maintaining the right niche for blood cell development

In your home, storing books on a bookshelf, tools in a tool box, and a broom in a broom cupboard makes it easy to access these items whenever you need them. Within the body, hematopoietic stem cells (HSCs) reside in their ...

Study identifies how blood stem cells maintain their fate

Understanding the molecular mechanisms that specify and maintain the identities of more than 200 cell types of the human body is arguably one of the most fundamental problems in molecular and cellular biology, with critical ...

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