Related topics: protein

Immunoproteasome crystal structure determined

Like a shredder, the immunoproteasome cuts down proteins into peptides that are subsequently presented on the cellular surface. The immune system can distinguish between self and nonself peptides and selectively kills cells ...

Active compounds against Alzheimer's disease

More than half of all cases of dementia in the elderly can be attributed to Alzheimer's disease. Despite vast research efforts, an effective therapy has not been developed, and treatment consists of dealing with the symptoms. ...

New class of drugs for the reversible inhibition of proteasomes

As the "recycling plant" of the cell, the proteasome regulates vitally important functions. When it is inhibited, the cell chokes on its own waste. Cancer cells, in particular, are very sensitive because they need the proteasome ...

Biochemists identify how tissue cells detect and perfect

Scientists have discovered how cells detect tissue damage and modify their repair properties accordingly. The findings, published today [6 October] in the journal Developmental Cell, could open up new opportunities for improving ...

Long-standing plant biochemistry mystery solved

Scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory and collaborators at the Karolinska Institute in Sweden have discovered how an enzyme "knows" where to insert a double bond when desaturating ...

A chaperone for the 'guardian of the genome'

The protein p53 plays an essential role in the prevention of cancer by initiating the controlled death of a cell with damaged genes which is in danger to transform into a cancerous cell. The heat shock protein Hsp90, in turn, ...

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