Understanding how RNA binding proteins control the genetic splicing code is fundamental to human biology and disease – much like editing film can change a movie scene. Abnormal variations in splicing are often implicated ...
Biotechnology
Feb 16, 2012
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Studying sequence and function of DNA has been in the focus of life sciences for decades, but now the interest of many researchers has turned to the RNA. Today, many scientists believe that RNA molecules, together with a ...
Cell & Microbiology
Apr 4, 2016
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In nearly every organism's genome, scattered between genes that encode proteins, long regulatory regions stretch across expanses of DNA. Understanding what role these so-called enhancer regions play in controlling the activation ...
Biotechnology
Jul 1, 2013
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The transporter protein ABCG2 belongs to the ATP-binding-cassette (ABC) family. The protein is expressed in the plasma membranes of cells within a variety of tissues and tissue barriers, including the blood-brain, blood-testes ...
With mutations, it turns out that context can be everything in determining whether or not they are beneficial to their evolutionary fate.
Evolution
Jun 13, 2013
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Delivering functional genes into cells to replace mutated genes, an approach known as gene therapy, holds potential for treating many types of diseases. The earliest efforts to deliver genes to diseased cells focused on DNA, ...
Biochemistry
Oct 16, 2018
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A team led by David Reverter, a researcher at the Institute of Biotechnology and Biomedicine (IBB) of the UAB, has determined for the first time the three-dimensional structure of a protein pair: LC8 and Nek9. Depending on ...
Biochemistry
Apr 10, 2013
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They can be found everywhere -- organized communities of bacteria sticking to surfaces both inside and outside the body. These biofilms are responsible for some of the most virulent, antibiotic-resistant infections in humans; ...
Cell & Microbiology
Jun 24, 2011
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Harvard Medical School scientists have identified a new family of proteins that virtually all bacteria use to build and maintain their cell walls.
Cell & Microbiology
Aug 15, 2016
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Researchers at UT Southwestern Medical Center have identified a second role for a class of RNA-binding proteins, revealing new insights about neurological diseases and conditions associated with this protein such as autism, ...
Cell & Microbiology
Mar 17, 2016
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