A study published in Science Bulletin has been led by Prof. Chao Wang (China Agricultural University), Prof. Guoliang Xia (China Agricultural University) and Prof. Fengchao Wang (National Institute of Biological Sciences).
Cell & Microbiology
Apr 9, 2024
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22
Autophagy is a process used by cells as a recycling system to transport and break down organelles and other cytosolic components, which become enveloped in a membrane called the autophagosome. When this involves the removal ...
Cell & Microbiology
Mar 14, 2024
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66
Autophagy is a self-eating process for recycling and rejuvenating cellular organelles and components. Intracellular calcium dynamics has been shown to be essential for the initiation of the autophagy process.
Cell & Microbiology
Mar 6, 2024
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10
A promising new fungicide to fight devastating crop diseases has been identified by researchers at the University of California, Davis. The chemical, ebselen, prevented fungal infections in apples, grapes, strawberries, tomatoes ...
Molecular & Computational biology
Feb 29, 2024
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55
Even the genes and proteins that have been most closely studied are still far from having given up all their secrets. Like a Swiss Army knife, they have many different, often unknown functions.
Cell & Microbiology
Feb 21, 2024
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1
Organogenesis, an important aspect of flowering, helps reveal key processes of plant development such as the formation of floral organs, attainment of reproductive capability, and abscission leading to seed and fruit development.
Plants & Animals
Feb 7, 2024
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2
Autophagy, which declines with age, may hold more mysteries than researchers previously suspected. In the January 4th issue of Nature Aging, it was noted that scientists from the Buck Institute, Sanford Burnham Prebys and ...
Cell & Microbiology
Jan 4, 2024
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31
A research group led by Professor Nobuo Noda of Hokkaido University has reconstituted the membrane invagination process required to form autophagosomes in vitro for the first time, showing that this process is mediated by ...
Molecular & Computational biology
Dec 20, 2023
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2
Recycling is just as essential in cells as in our more familiar macroscopic world. Cells continuously generate waste products and accumulate damaged components while performing regular functions. Various recycling mechanisms ...
Cell & Microbiology
Nov 2, 2023
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19
Maintaining the structure of intracellular membranes is essential for preserving normal cellular function. New research by a team of biochemists at Umeå University identifies a strategy employed by cells to detect and repair ...
Cell & Microbiology
Sep 20, 2023
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6
In cell biology, autophagy, or autophagocytosis, is a catabolic process involving the degradation of a cell's own components through the lysosomal machinery. It is a tightly regulated process that plays a normal part in cell growth, development, and homeostasis, helping to maintain a balance between the synthesis, degradation, and subsequent recycling of cellular products. It is a major mechanism by which a starving cell reallocates nutrients from unnecessary processes to more-essential processes.
A variety of autophagic processes exist, all having in common the degradation of intracellular components via the lysosome. The most well-known mechanism of autophagy involves the formation of a membrane around a targeted region of the cell, separating the contents from the rest of the cytoplasm. The resultant vesicle then fuses with a lysosome and subsequently degrades the contents.
It was first described in the 1960s, but many questions about the actual processes and mechanisms involved still remain to be elucidated. Its role in disease is not well categorized; it may help to prevent or halt the progression of some diseases such as some types of neurodegeneration and cancer, and play a protective role against infection by intracellular pathogens; however, in some situations, it may actually contribute to the development of a disease.
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