A research group led by Professor Nobuo Noda of Hokkaido University has reconstituted the membrane invagination process required to form autophagosomes in vitro for the first time, showing that this process is mediated by ...
Molecular & Computational biology
Dec 20, 2023
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2
A "hub and spoke" system enables plant cells to efficiently coordinate cellular trafficking, particularly for cellular recycling, the so-called autophagy process. Specialized vesicles, the autophagosomes, engulf harmful molecules ...
Cell & Microbiology
Oct 19, 2022
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11
Drs. Nobuo Noda (Director) and Tatsuro Maruyama (Researcher) et al. at the Institute of Microbial Chemistry (BIKAKEN, Tokyo, Japan) discovered that lipidated Atg8, the most famous factor that mediates autophagy, has membrane ...
Cell & Microbiology
Jul 9, 2021
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4
Scientists at Sanford Burnham Prebys have gained a deeper insight into the intricacies of autophagy, the process in which cells degrade and recycle cellular components. The findings, published in Current Biology, describe ...
Cell & Microbiology
Jun 18, 2021
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734
Dr. Nobuo Noda and Dr. Kazuaki Matoba at the Institute of Microbial Chemistry discovered that Atg9, one of the proteins that function to mediate autophagy, has phospholipid-translocation activity (the lipid scramblase activity) ...
Cell & Microbiology
Nov 4, 2020
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5
Autophagy, from the Greek for "self-eating," is an essential process that isolates and recycles cellular components under conditions of stress or when resources are limited. Cargoes such as misfolded proteins or damaged organelles ...
Cell & Microbiology
Sep 4, 2020
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131
Postdoctoral Researcher Tetsuya Kotani, Associate Professor Hitoshi Nakatogawa, Honorary Professor Yoshinori Ohsumi and colleagues at Tokyo Institute of Technology have analyzed the Atg protein Atg2, whose function was previously ...
Cell & Microbiology
Oct 23, 2018
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11
Cells collect, decompose and recycle surplus or damaged cell material. This process, known as autophagy, is important, because cellular waste can be harmful to the entire organism if it accumulates in the cells. Like the ...
Cell & Microbiology
Aug 14, 2018
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3
