When the human genome was first sequenced, experts predicted they would find about 100,000 genes. The actual number has turned out to be closer to 20,000, just a few thousand more than fruit flies have. The question logically ...
Cell & Microbiology
Dec 31, 2014
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In a recent paper in RNA Biology, researchers show that mitochondria translocate their key RNA methyltransferase enzyme, TRMT1, into host cell nuclei in response to neural activity. This subcellular relocalization of key ...
In a development that could accelerate the discovery of new diagnostics and treatments, researchers at Children's Hospital of Philadelphia (CHOP) have developed a versatile and low-cost technology for targeted sequencing ...
Molecular & Computational biology
Aug 15, 2023
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RNA is the key functional component of spliceosomes, molecular machines that control how genes are expressed, report scientists from the University of Chicago online, Nov. 6 in Nature. The discovery establishes that RNA, ...
Cell & Microbiology
Nov 6, 2013
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On the journey from gene to protein, a nascent RNA molecule can be cut and joined, or spliced, in different ways before being translated into a protein. This process, known as alternative splicing, allows a single gene to ...
Molecular & Computational biology
Jan 20, 2023
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Some three billion base pairs make up the human genome—the floor plan of life. In 2003, the Human Genome Project announced the successful decryption of this code, a tour de force that continues to supply a stream of insights ...
Bio & Medicine
Apr 6, 2014
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A study led by researchers at the University of California, San Diego School of Medicine shines a new light on molecular tools our cells use to govern regulated gene expression. The study was published on line in advance ...
Cell & Microbiology
Nov 10, 2013
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When genes were first discovered, the canonical view was that each gene encodes a unique protein. However, biologists later found that segments of genes can be combined in different ways, giving rise to many different proteins.
Evolution
Dec 21, 2012
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Too early or too late blooming can have serious consequences for plants: It may reduce the seed harvest and jeopardize the reproductive success of an entire season. In order not to miss the optimal time of flowering, plants ...
Biotechnology
Sep 25, 2013
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Alternative splicing of mRNA precursors enables cells to generate different protein outputs from the same gene depending on their developmental or homeostatic status. It is a complex process that allows the generation of ...
Biochemistry
Dec 23, 2015
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