CRISPR-HOT: A new tool to 'color' specific genes and cells

Researchers from the group of Hans Clevers at the Hubrecht Institute have developed a new genetic tool to label specific genes in human organoids, or mini organs. They used this new method, called CRISPR-HOT, to investigate ...

Why premature cell division promotes cancers

The accumulation of mutations in the human genome is at the origin of cancers, as well as the development of resistance to treatments. The Cyclin E and Myc genes are active in the control of cell division. When they mutate ...

Scientists provide new insights into gene regulation

A team of researchers led by the University of Leicester has shed new light on how the regulation machinery that controls gene expression works by characterising a complex known as the NuRD complex.

New dwarfism mutation identified in dogs

Professor Hannes Lohi's research group at the University of Helsinki and Folkhälsan Research Center has identified a mutation in ITGA10 gene, causing chondrodysplasia in two dog breeds, the Norwegian Elkhound and the Karelian ...

From fish to man: Research reveals how fins became legs

Vertebrates' transition to living on land, instead of only in water, represented a major event in the history of life. Now, researchers reporting in the December issue of the journal Developmental Cell provide new evidence ...

Scientists uncover role for cell scaffold in tumor formation

A group of scientists at the Instituto Gulbenkian de Ciencia, in Portugal, have uncovered a surprising link between the cell's skeleton and organ size. The team, led by Florence Janody, show in the journal Development, that ...

A yeast cancer model for mapping cancer genes

Researchers have devised a scheme for identifying genes in yeast that could lead to the identification of new cancer genes in humans. The study is published online this week in the open-access journal PLoS Biology.

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