https://phys.org/ en-us Latest news from University Health Network An international consortium of researchers led by University Health Network (UHN) in Toronto and University of Zurich have built the first-ever molecular atlas of the human brain vasculature at single-cell resolution, spanning from early development to adulthood and through disease stages such as brain tumors and brain vascular malformations. https://medicalxpress.com/news/2024-07-molecular-atlas-blood-vessel-pathways.html Genetics Wed, 10 Jul 2024 12:01:04 EDT news639831661 An international research team led by Krembil Brain Institute Neurologist and Senior Scientist, Dr. Anthony Lang, has proposed a new model for classifying Parkinson's disease (PD). https://medicalxpress.com/news/2024-01-radically-parkinson-disease.html Neuroscience Mon, 22 Jan 2024 18:30:01 EST news625134971 A new international study published in Nature Medicine and presented as a late-breaking abstract at the American Association of Neurological Surgeons (AANS) annual conference, shows great promise for patients with glioblastoma. https://medicalxpress.com/news/2023-05-approach-glioblastoma-treatment-results-survival.html Oncology & Cancer Mon, 15 May 2023 11:00:03 EDT news603362283 Storing donor lungs for transplant at 10 degrees Celsius markedly increases the length of time the organ can live outside the body according to research led by a team of scientists at the Toronto Lung Transplant Program in the Ajmera Transplant Centre at the University Health Network (UHN). https://medicalxpress.com/news/2023-04-clinical-trial-paradigm-shift-lung.html Surgery Thu, 20 Apr 2023 12:48:39 EDT news601213716 A single-dose of the antiviral drug peginterferon lambda reduced by half the risk of hospitalization or a visit to the Emergency Department due to COVID-19, according to a study published today in the New England Journal of Medicine. https://medicalxpress.com/news/2023-02-single-dose-treatment-covid-hospitalization-high-risk.html Medications Wed, 08 Feb 2023 17:00:02 EST news595094390 In a new study published today in Cell Reports, researchers from the Donald K. Johnson Eye Institute (DKJEI), part of the Krembil Research Institute at University Health Network, have identified previously unknown connections between genetic factors in autism spectrum disorder (ASD). https://medicalxpress.com/news/2022-11-genetic-factors-autism-spectrum-disorder.html Genetics Tue, 22 Nov 2022 11:00:06 EST news588335971 A team of scientists from the Krembil Brain Institute, part of the University Health Network in Toronto, and Duke University in Durham, North Carolina, has developed the first computer model predicting the role of cortical glial cells in cognition. https://medicalxpress.com/news/2022-10-paves-theory-cognitive.html Neuroscience Wed, 19 Oct 2022 14:40:16 EDT news585409213 Scientists at the Krembil Brain Institute, part of the University Health Network, have proposed a new mechanistic model (AD2) for Alzheimer's, looking at it not as a brain disease, but as a chronic autoimmune condition that attacks the brain. https://medicalxpress.com/news/2022-09-alzheimer-autoimmune-disease.html Alzheimer's disease & dementia Tue, 27 Sep 2022 07:21:23 EDT news583482062 A study published in the Journal of the American Medical Association Surgery is the first in North America to demonstrate that living-donor liver transplant is a viable option for patients who have systemically controlled colorectal cancer and liver tumors that cannot be surgically removed. https://medicalxpress.com/news/2022-03-donation-doors-colorectal-cancer-patients.html Oncology & Cancer Wed, 30 Mar 2022 11:00:10 EDT news567844612 A study published in Science Translational Medicine performed at the Latner Thoracic Surgery Research Laboratories and UHN's Ajmera Transplant Center has proved that it is possible to convert blood type safely in donor organs intended for transplantation. This finding is an important step towards creating universal type O organs, which would significantly improve fairness in organ allocation and decrease mortality for patients in the waitlist. https://medicalxpress.com/news/2022-02-universal-blood-type-transplant.html Medical research Wed, 16 Feb 2022 14:00:02 EST news564223328 Precision medicine requires big data. In order to improve the treatment of individuals with cancer, or to understand rare diseases, scientists and clinicians, as well as AI technologies require access to larger sets of health research data that covers diverse populations and wide ranges of conditions. For AI, more data means a better understanding of diseases, which will lead to more accurate diagnosis and treatment. At the same time, each hospital will only see a relatively small number of individuals with a disease, and even across the province, we have access to only a small portion of the total data available worldwide. To build the large-scale datasets needed to drive forward precision medicine, sharing of data across the country and around the world is critical. https://medicalxpress.com/news/2021-11-dots-health.html Genetics Thu, 18 Nov 2021 10:45:17 EST news556454713 In a paper published today in the journal Science Translational Medicine, researchers at the Schroeder Arthritis Institute, part of University Health Network (UHN) in Toronto, have made a discovery that could lead to new treatments for axial spondyloarthritis (SpA), a painful and debilitating form of arthritis which affects 1-2% of Canadians and causes inflammation in the spine, joints, eyes, gut and skin. https://medicalxpress.com/news/2021-10-discovery-potential-therapy-inflammatory-arthritis.html Arthritis & Rheumatism Wed, 20 Oct 2021 14:00:05 EDT news553942619 Princess Margaret Cancer Centre researchers have made new findings that greatly improve detection of the human papillomavirus (HPV) in the bloodstream and could further hone precision treatment of the illness. https://medicalxpress.com/news/2021-09-refine-ultrasensitive-hpv-bloodstream.html Oncology & Cancer Mon, 27 Sep 2021 15:01:46 EDT news551973702 Scientists with the Ajmera Transplant Centre at UHN have conducted a first-in-the-world randomized placebo-controlled trial of third dose COVID-19 booster vaccine for transplant patients that shows substantially improved protection. https://medicalxpress.com/news/2021-08-world-first-covid-vaccine-booster-randomized.html Vaccination Thu, 12 Aug 2021 01:57:13 EDT news547952226 Princess Margaret Cancer Centre researchers have made new findings which provide a broader understanding of how dormant hematopoietic stem cells are activated and could pave the way towards therapeutic treatments for a number of cancers. https://medicalxpress.com/news/2021-08-key-stem-cell-dormancy-mechanism.html Medical research Mon, 02 Aug 2021 11:07:08 EDT news547121223 A new population-based study looking at nearly 30 years of billing data demonstrates that sex-based differences in Ontario Health Insurance Plan (OHIP) payments exists for Canadian ophthalmologists. https://medicalxpress.com/news/2021-07-disparity-female-ophthalmologists-ontario-canada.html Medical economics Tue, 13 Jul 2021 07:18:30 EDT news545379504 For the first time, Princess Margaret researchers have mapped out where and how leukemia begins and develops in infants with Down syndrome in preclinical models, paving the way to potentially prevent this cancer in the future. https://medicalxpress.com/news/2021-07-leukemia-children-syndrome.html Medical research Thu, 08 Jul 2021 14:00:02 EDT news544951932 The impact of deploying Artificial Intelligence (AI) for radiation cancer therapy in a real-world clinical setting has been tested by Princess Margaret researchers in a unique study involving physicians and their patients. https://medicalxpress.com/news/2021-06-ai-outperforms-humans-cancer-treatments.html Oncology & Cancer Thu, 03 Jun 2021 11:00:04 EDT news541920126 Probing the unique biology of human pancreatic cancer cells in a laboratory has yielded unexpected insights of a weakness that can be used against the cells to kill them. https://medicalxpress.com/news/2021-05-pancreatic-cancer-cell-addiction-death.html Medical research Fri, 07 May 2021 14:00:01 EDT news539604026 Scientists at the Krembil Brain Institute, part of University Health Network (UHN), in collaboration with colleagues at the Centre for Addiction and Mental Health (CAMH), have used precious and rare access to live human cortical tissue to identify functionally important features that make human neurons unique. https://medicalxpress.com/news/2021-05-unique-characteristics-human-neurons.html Neuroscience Mon, 03 May 2021 05:06:50 EDT news539237204 Combining immune-boosting drugs with radiation and surgery increased the survival and anticancer immune response in mouse models of mesothelioma in preclinical research by Princess Margaret Cancer Centre researchers. https://medicalxpress.com/news/2021-04-triple-combination-therapy-rare-deadly.html Medications Wed, 14 Apr 2021 14:00:05 EDT news537617480 Researchers from University Health Network have developed and validated an innovative deep learning model to predict a patient's long-term outcome after receiving a liver transplant. https://medicalxpress.com/news/2021-04-deep-maximize-lifespan-liver-transplant.html Surgery Tue, 13 Apr 2021 03:37:03 EDT news537503818 University Health Network has performed what is believed to be the first lung transplant in Canada on a patient whose lungs were irreparably damaged by COVID-19. https://medicalxpress.com/news/2021-04-double-lung-transplant-covid-canada.html Diseases, Conditions, Syndromes Mon, 12 Apr 2021 10:58:45 EDT news537443921 For the first time, an app has been shown to reduce key symptoms of chronic pain. A UHN-led study evaluated the impact of Manage My Pain (MMP), a digital health solution developed by ManagingLife, on patients seen at the Iroquois Falls Family Health Team, and the Toronto Western and Toronto General Hospitals. https://medicalxpress.com/news/2021-03-digital-app-chronic-pain.html Neuroscience Thu, 04 Mar 2021 12:27:37 EST news534083253 Results of a world-first Canadian pilot study on patients treated with gene therapy for Fabry disease show that the treatment is working and safe. https://medicalxpress.com/news/2021-02-canadian-success-story-world-first-fabry.html Medical research Thu, 25 Feb 2021 12:08:19 EST news533477294 Creating "super soldiers" of specific white blood cells to boost an anti-tumor response has been shown in a series of elegant experiments by Princess Margaret researchers. https://medicalxpress.com/news/2021-02-turbocharging-power-immune-cells-cancer.html Oncology & Cancer Fri, 19 Feb 2021 12:52:55 EST news532961572 Using advanced RNA sequencing, scientists have identified two unique subtypes of a prominent mutation present in many patients with Acute Myeloid Leukemia (AML)—called NPM1—that could help predict survival and improve treatment response for patients whose leukemic cells bear the mutation. https://medicalxpress.com/news/2021-02-classification-leukemia-subtypes-reveals-potential.html Oncology & Cancer Tue, 16 Feb 2021 12:21:05 EST news532700462 Inhibiting a key enzyme that controls a large network of proteins important in cell division and growth paves the way for a new class of drugs that could stop glioblastoma, a deadly brain cancer, from growing. https://medicalxpress.com/news/2021-02-approach-growth-brain-cancer-cells.html Medical research Fri, 12 Feb 2021 05:00:05 EST news532327940 A clinical study led by Dr. Jordan Feld, a liver specialist at Toronto Centre for Liver Disease, University Health Network (UHN), showed an experimental antiviral drug can significantly speed up recovery for COVID-19 outpatients—patients who do not need to be hospitalized. https://medicalxpress.com/news/2021-02-peginterferon-lambda-strong-antiviral-action-clearance.html Diseases, Conditions, Syndromes Sat, 06 Feb 2021 13:02:23 EST news531838935 Results of a multi-centre, international, clinical trial co-led by Peter Munk Cardiac Centre (PMCC) cardiologist Dr. Dinesh Thavendiranathan point to the benefit of using a more sensitive test to detect heart function issues early, so cancer patients don't have to fight heart failure too. https://medicalxpress.com/news/2021-02-early-heart-problems-chemotherapy.html Cardiology Tue, 02 Feb 2021 06:49:25 EST news531470956