https://phys.org/ en-us Latest news from Trudeau Institute New research from the laboratory of Dr. Andrea Cooper at the Trudeau Institute, just published in the European Journal of Immunology, holds promise for the improved prevention and treatment of bacterial infections and the life-threatening complications of chronic inflammation that can result from them. The publication title is "Nitric oxide inhibits the accumulation of CD4+CD44hiTbet+CD69lo T cells in mycobacterial infection". https://medicalxpress.com/news/2012-08-unforeseen-anti-bacterial-immune-response.html Immunology Tue, 28 Aug 2012 12:36:46 EDT news265376195 New research from the Trudeau Institute addresses how the human body controls gamma-herpesviruses, a class of viruses thought to cause a variety of cancers. The study, carried out in the laboratory of Dr. Marcia Blackman, awaits publication in The Journal of Immunology. Led by postdoctoral fellow Mike Freeman, with assistance from other laboratory colleagues, the study describes the role of white blood cells in controlling gamma-herpesvirus infections and has implications for the treatment and prevention of certain cancers. https://medicalxpress.com/news/2012-03-implications-cancers-viruses.html Immunology Mon, 12 Mar 2012 17:01:15 EDT news250790469 New research from the laboratory of Dr. Elizabeth Leadbetter at the Trudeau Institute may lead to a whole new class of vaccines. Dr. Leadbetter's lab has discovered new properties of a potential vaccine adjuvant that suggest it could be useful for enhancing protection against a number of different infections. This new data will be published in the January 2012 issue of the journal Nature Immunology (Vol. 13, pp. 44-50). The paper, "iNKT cells direct B cell responses to cognate lipid antigen in an interleukin 21-dependent manner," is now available through Advance Online Publication (AOP) on Nature Immunology's website. https://medicalxpress.com/news/2011-12-advantages-vaccine-adjuvant.html Medical research Mon, 12 Dec 2011 12:00:04 EST news242912269 New research from the Trudeau Institute may help in the ongoing fight against tuberculosis. Dr. Andrea Cooper's lab has discovered a connection between the development of new lymphoid tissue within the lung and protection against the disease. The new data will be published in the November 1 print issue of The Journal of Immunology (Vol. 187, Num. 10) and is available now online ahead of print. https://medicalxpress.com/news/2011-10-latest-discovery-tuberculosis.html Diseases, Conditions, Syndromes Tue, 18 Oct 2011 09:37:02 EDT news238149372 Research underway at the Trudeau Institute could lead to new treatments for people sickened by Listeria and other sepsis-causing bacteria. Dr. Stephen Smiley's laboratory has published a study in the scientific journal Infection and Immunity that supports a new approach to treating these infections. https://medicalxpress.com/news/2011-10-trudeau-approach-listeria-infections.html Diseases, Conditions, Syndromes Mon, 17 Oct 2011 16:37:20 EDT news238088231 New research from the Trudeau Institute may help to explain why live attenuated influenza vaccine (LAIV), commonly known as FluMist, elicits protection. The research is published in this month's issue of Vaccine. The journal article is entitled "Live attenuated influenza vaccine (LAIV) impacts innate and adaptive immune responses" and was authored by Trudeau Institute scientist Dr. Laura Haynes and her colleagues. https://medicalxpress.com/news/2011-08-discovery-flumist-elicits.html Medical research Tue, 23 Aug 2011 10:38:38 EDT news233314703 New research from the Trudeau Institute may help to explain why anticoagulant therapies have largely failed to extend the lives of patients with sepsis. The study was led by Deyan Luo, a postdoctoral fellow in Stephen Smiley's laboratory. It shows that fibrin, a key product of the blood clotting process, is critical for host defense against Yersinia enterocolitica, a gram-negative bacterium that causes sepsis in humans and experimental mice. The new data will be published in the August 15 issue of The Journal of Immunology and is available now online ahead of print. https://medicalxpress.com/news/2011-07-discovery-sepsis.html Medical research Mon, 11 Jul 2011 12:36:24 EDT news229606573 Researchers from the Smiley lab at the Trudeau Institute have now identified a single component of the plague causing bacterium that can be used as a vaccine. This single "subunit" could potentially be used to create a safer form of a T cell-stimulating plague vaccine. The new data is featured in the July issue of The Journal of Immunology. https://medicalxpress.com/news/2011-06-discovery-plague-bacterial-pneumonias.html Medical research Mon, 27 Jun 2011 10:30:22 EDT news228389412 There is an ongoing battle in the "war on terror" that remains mostly unseen to the public -- a race between scientists working to develop a vaccine to protect against plague and the terrorists who seek to use plague as a weapon. https://medicalxpress.com/news/2011-01-discovery-vaccines-plague-bacterial-pneumonias.html Medical research Tue, 25 Jan 2011 10:55:16 EST news215175195 A collaborative project between researchers at the Trudeau Institute and their colleagues at St. Jude Children's Research Hospital in Memphis, Tenn., offers new insights that may lead to an improved strategy to protect against the influenza virus and other viruses that infect the respiratory tract. https://medicalxpress.com/news/2011-01-vaccines-respiratory-infections.html Medical research Tue, 18 Jan 2011 10:54:53 EST news214570483 A billion people living in underdeveloped areas around the world are infected with parasitic helminthes, worms that survive by residing in and feeding on their hosts. These infestations can cause chronic intestinal (and occasionally systemic) illnesses leading to long-term disability. Irah King and Markus Mohrs, biomedical researchers at the Trudeau Institute, are investigating illnesses caused by these gut-dwelling worms in an effort to decipher how immune cells send and receive signals that determine the specific immune response to mount. https://medicalxpress.com/news/2010-10-illnesses-worms-scientists-immune-cells.html Medical research Fri, 08 Oct 2010 13:54:55 EDT news205764886 Given the many pressing concerns of the day, fear of plague probably isn't what causes most Americans to lose sleep. But for those whose responsibility it is to combat bioterrorism, plague is among the highest priorities. Those charged with that mission include scientists like medical researcher Steve Smiley, whose lab at the Trudeau Institute is working to develop a vaccine that will protect the public against weaponized forms of plague. The Institute, which is dedicated to studying how the immune system responds to infectious diseases, is at the forefront of an international effort to protect the public against an ominous foe, whose very name conjures up images of widespread suffering and death. https://phys.org/news/2010-09-plague-bioterrorists.html Biochemistry Mon, 20 Sep 2010 11:40:02 EDT news204200410 Inducing cellular immunity as a means to protect against influenza virus is the focus of several laboratories at the Trudeau Institute. Researchers here have recently identified two important signaling components required by the immune system that might allow us to pre-position our own virus-fighting T cells to the lungs, the site of initial infection. https://medicalxpress.com/news/2010-05-immune-traffic-signposts-lung.html Medical research Mon, 10 May 2010 12:54:46 EDT news192714873 According to the World Health Organization, two billion people around the globe suffer from chronic parasitic worm infections, which, in addition to causing illness and developmental delay, are also suspected to interfere with the effectiveness of ordinary vaccines, making their victims more vulnerable to life-threatening diseases. A recent discovery by researchers at the Trudeau Institute promises to bypass these obstacles and help deliver more effective vaccines to these people, boosting their protection against common childhood diseases. https://medicalxpress.com/news/2010-04-scientists-favor-needles-tablets-global.html Medical research Mon, 26 Apr 2010 13:40:02 EDT news191506743 A new study from the Trudeau Institute in Saranac Lake, New York, demonstrates that immune system cells important for both pathogen resistance and vaccine efficacy live longer in older animals but because of this longevity acquire functional defects. The work may provide new targets for boosting immune system function in older individuals. https://medicalxpress.com/news/2009-10-aging-vaccine-efficacy-elderly.html Medical research Mon, 05 Oct 2009 15:26:52 EDT news173975148 Schistosomiasis, one of the most important of the neglected tropical diseases, is caused by infection with parasitic helminths of the genus Schistosoma. These parasites are long lived (>10 years) and dwell within blood vessels, where they produce eggs that become the focus of intense, chronic inflammatory responses. In severe cases, this inflammation is associated with life-threatening liver disease. https://medicalxpress.com/news/2009-07-discovery-aid-future-treatments-third-world.html Medical research Mon, 27 Jul 2009 14:50:02 EDT news167923493 Dr. Marcia Blackman and her research team at the Trudeau Institute have followed up on an intriguing report published in the journal Nature in May 2007 by Dr. Herbert Virgin, et al., showing that mice persistently infected with certain forms of herpesvirus, which can establish lifelong latent infections, are resistant to infection with bacterial pathogens. https://medicalxpress.com/news/2009-02-herpes-virus-vaccinate.html Medical research Thu, 12 Feb 2009 13:59:12 EST news153669519 Findings just published in the scientific journal Immunity by researchers at the Trudeau Institute shed new light on how a previously-unknown messaging mechanism within the human immune system prompts specific influenza-fighting cells to the lung airways during an infection. https://medicalxpress.com/news/2008-07-mobilizing-white-blood-cells-lung.html Diseases, Conditions, Syndromes Thu, 10 Jul 2008 13:25:44 EDT news134915144