https://phys.org/ en-us Latest news from National Institute of Diabetes and Digestive and Kidney Diseases In a major breakthrough toward understanding and treating kidney disease, a nationwide research team has created the most comprehensive atlas of the human kidney. Data from the Kidney Tissue Atlas will allow the comparison of healthy kidney cells to those injured by kidney disease, helping investigators understand the factors that contribute to the progression of kidney disease and kidney failure or recovery from injury. https://medicalxpress.com/news/2023-07-atlas-human-kidney-cells-disease.html Medical research Wed, 19 Jul 2023 11:00:01 EDT news608982276 In a large clinical trial that directly compared four drugs commonly used to treat type 2 diabetes, researchers found that insulin glargine and liraglutide performed the best of four medications approved by the U.S. Food and Drug Administration to maintain blood glucose levels in the recommended range. Blood glucose management is a key component of keeping people with type 2 diabetes healthy. All four medications evaluated were added to treatment with metformin, which is the first-line drug to treat type 2 diabetes. https://medicalxpress.com/news/2022-09-popular-diabetes-drugs-outperform-large.html Medications Wed, 21 Sep 2022 17:00:04 EDT news582995178 Masks help protect the people wearing them from getting or spreading SARS-CoV-2, the virus that causes COVID-19, but now researchers from the National Institutes of Health have added evidence for yet another potential benefit for wearers: The humidity created inside the mask may help combat respiratory diseases such as COVID-19. https://medicalxpress.com/news/2021-02-humidity-masks-lessen-severity-covid-.html Diseases, Conditions, Syndromes Fri, 12 Feb 2021 16:10:13 EST news532368606 People on a low-fat, plant-based diet ate fewer daily calories but had higher insulin and blood glucose levels, compared to when they ate a low-carbohydrate, animal-based diet, according to a small but highly controlled study at the National Institutes of Health. Led by researchers at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the study compared the effects of the two diets on calorie intake, hormone levels, body weight, and more. The findings, published in Nature Medicine, broaden understanding of how restricting dietary carbohydrates or fats may impact health. https://medicalxpress.com/news/2021-01-low-fat-plant-based-diet-low-carb-animal-based.html Health Tue, 19 Jan 2021 12:25:58 EST news530281554 A clinical trial at four pediatric diabetes centers in the United States has found that a new artificial pancreas system—which automatically monitors and regulates blood glucose levels—is safe and effective at managing blood glucose levels in children as young as age six with type 1 diabetes. The trial was funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health. Results from the trial were published August 26 in the New England Journal of Medicine. https://medicalxpress.com/news/2020-08-artificial-pancreas-effectively-diabetes-children.html Diabetes Wed, 26 Aug 2020 17:00:02 EDT news517656068 Funded by the National Institutes of Health, six U.S. research institutions are launching the first-ever multicenter network to study diabetic foot ulcers, a common and burdensome complication of diabetes and the leading cause of lower limb amputations in the United States. The Diabetic Foot Consortium (DFC) aims to lay the foundation for a clinical trial network to test how to improve diabetic wound healing and prevent amputations among the 27 million American adults with diabetes. The DFC is supported by the NIH's National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). https://medicalxpress.com/news/2020-07-first-ever-network-tackles-diabetic-foot.html Diabetes Fri, 24 Jul 2020 15:52:35 EDT news514824750 Researchers at the National Institutes of Health developed a new mouse model that could improve the translation of research in mice into advances in human health. The mouse model, which the scientists called "wildling," acquired the microbes and pathogens of wild mice, while maintaining the laboratory mice's genetics that make them more useful for research. In two preclinical studies, wildlings mirrored human immune responses, where lab mice failed to do so. Led by scientists at the NIH's National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the study published online in Science. https://medicalxpress.com/news/2019-08-wildling-mice-results-animal-humans.html Medical research Thu, 01 Aug 2019 14:00:01 EDT news483879692 A set of clinical trials examining youth and adults with type 2 diabetes or impaired glucose tolerance has found that disease progression in adults slowed during medical treatment but resumed after treatment stopped. Youth on the same treatment had markedly poorer outcomes with continued disease progression both during and after the treatment. This research, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), was published June 9 in the journals Diabetes and Diabetes Care and presented at the American Diabetes Association Scientific Sessions in San Francisco. NIDDK is part of the National Institutes of Health. https://medicalxpress.com/news/2019-06-insulin-wane-treatment-adults-diabetes.html Diabetes Mon, 10 Jun 2019 03:48:36 EDT news479357305 A treatment affecting the immune system effectively slowed the progression to clinical type 1 diabetes in high risk individuals, according to findings from National Institutes of Health-funded research. The study is the first to show that clinical type 1 diabetes can be delayed by two or more years among people who are at high risk. These results were published online in The New England Journal of Medicine and presented at the American Diabetes Association Scientific Sessions in San Francisco. https://medicalxpress.com/news/2019-06-drug-diabetes-people-high.html Diabetes Mon, 10 Jun 2019 03:30:59 EDT news479356242 Taking a daily vitamin D supplement does not prevent type 2 diabetes in adults at high risk, according to results from a study funded by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health. The Vitamin D and Type 2 Diabetes (D2d) study enrolled 2,423 adults and was conducted at 22 sites across the United States. These findings were published June 7 in the New England Journal of Medicine and presented at the 79th Scientific Sessions of the American Diabetes Association in San Francisco. https://medicalxpress.com/news/2019-06-trial-vitamin-d-diabetes-people.html Health Fri, 07 Jun 2019 15:45:56 EDT news479141148 Despite similar weight loss, teens who had gastric bypass surgery were significantly more likely to have remission of both type 2 diabetes and high blood pressure, compared to adults who had the same procedure. Results are from an NIH-funded study comparing outcomes in the two groups five years after surgery. Previously, no treatment has shown longer-term effectiveness at reversing type 2 diabetes in youth, which tends to advance more quickly than in adults. https://medicalxpress.com/news/2019-05-early-weight-loss-surgery-diabetes-blood.html Surgery Thu, 16 May 2019 12:02:39 EDT news477226947 Mothers with elevated blood glucose during pregnancy—even if not high enough to meet the traditional definition of gestational diabetes—were significantly more likely to have developed type 2 diabetes a decade after pregnancy than their counterparts without high blood glucose. https://medicalxpress.com/news/2018-09-high-blood-sugar-pregnancy-ups.html Diabetes Tue, 11 Sep 2018 11:00:15 EDT news455860389 Diabetes affects a body from head to toe. Now there's a resource that illustrates its effect on both—and all the parts in between. https://medicalxpress.com/news/2018-08-nih-one-stop-resource-diabetes-medical.html Diabetes Tue, 14 Aug 2018 11:20:31 EDT news453464417 In youth with impaired glucose tolerance or recent-onset type 2 diabetes, neither initial treatment with long-acting insulin followed by the drug metformin, nor metformin alone preserved the body's ability to make insulin, according to results published online June 25 in Diabetes Care. The publication is concurrent to a presentation of the results at the American Diabetes Association Scientific Sessions in Orlando, Florida. https://medicalxpress.com/news/2018-06-diabetes-medications-dont-youth.html Diabetes Mon, 25 Jun 2018 15:50:01 EDT news449153029 Adjusting the frequency of eye screenings for people with type 1 diabetes based on their risk of severe eye problems would result in fewer eye exams at lower cost and quicker diagnosis and treatment of advanced retinopathy, which can otherwise lead to vision loss. The findings, published April 19 in the New England Journal of Medicine, are the latest from an ongoing study funded for more than 30 years by the National Institutes of Health. https://medicalxpress.com/news/2017-04-exams-eye-health-aye-aye-diabetes.html Diabetes Wed, 19 Apr 2017 17:00:01 EDT news411821873 More than half of Asian Americans and nearly half of Hispanic Americans with diabetes are undiagnosed, according to researchers from the National Institutes of Health and the Centers for Disease Control and Prevention. Their results were published Sept. 8 in JAMA, the Journal of the American Medical Association. https://medicalxpress.com/news/2015-09-asian-americans-diabetes-undiagnosed.html Diabetes Tue, 08 Sep 2015 11:00:07 EDT news360922980 For the first time in a lab, researchers at the National Institutes of Health found evidence supporting the commonly held belief that people with certain physiologies lose less weight than others when limiting calories. Study results published May 11 in Diabetes. https://medicalxpress.com/news/2015-05-ease-weight-loss-individual-biology.html Diabetes Mon, 11 May 2015 14:00:03 EDT news350559757 An over-the-counter drug indicated to treat allergy symptoms limited hepatitis C virus activity in infected mice, according to a National Institutes of Health study. The results suggest that the drug, chlorcyclizine HCl (CCZ), potentially could be used to treat the virus in people. Results were published April 8 in Science Translational Medicine. https://medicalxpress.com/news/2015-04-allergy-drug-inhibits-hepatitis-mice.html Diseases, Conditions, Syndromes Wed, 08 Apr 2015 16:02:01 EDT news347727713 People with type 1 diabetes who intensively control their blood glucose (blood sugar) early in their disease are likely to live longer than those who do not, according to research funded by the National Institutes of Health. The findings are the latest results of the Diabetes Control and Complications Trial (DCCT) and its follow-up, the Epidemiology of Diabetes Control and Complications (EDIC) study. Results were published online Jan. 6 in the Journal of the American Medical Association. https://medicalxpress.com/news/2015-01-early-blood-glucose-lengthens-life.html Diabetes Tue, 06 Jan 2015 11:00:04 EST news339758936 Using two drugs was no more effective than a single drug in slowing disease progression in people with autosomal dominant polycystic kidney disease (ADPKD), according to two studies funded by the National Institutes of Health (NIH). One of the studies also showed that rigorous blood pressure treatment slowed growth of kidney cysts, a marker of ADPKD, but had little effect on kidney function compared to standard blood pressure treatment. https://medicalxpress.com/news/2014-11-drugs-effective-common-kidney-disease.html Diseases, Conditions, Syndromes Sat, 15 Nov 2014 11:55:47 EST news335274935 An experimental drug aimed at treating a common liver disease showed promising results and potential problems in a multicenter clinical trial funded by the National Institutes of Health. The FLINT study found that people with nonalcoholic steatohepatitis (NASH) who took obeticholic acid (OCA) had improved liver health during that period, including decreased inflammation and fat in the liver and decreased body weight versus people receiving a placebo. OCA was also associated with increases in itching and total cholesterol. https://medicalxpress.com/news/2014-11-drug-common-liver-disease-health.html Diseases, Conditions, Syndromes Thu, 06 Nov 2014 19:27:42 EST news334524451 People who are obese may be more susceptible to environmental food cues than their lean counterparts due to differences in brain chemistry that make eating more habitual and less rewarding, according to a National Institutes of Health study published in Molecular Psychiatry. https://medicalxpress.com/news/2014-09-habits-body-fat-differences-brain.html Psychology & Psychiatry Tue, 09 Sep 2014 04:51:14 EDT news329457061 Acute kidney injury (AKI) and chronic kidney disease (CKD) are closely intertwined, with each disease a risk factor for developing the other and sharing other risk factors in common, as well as sharing causes for the diseases to get worse, and outcomes, suggests a comprehensive analysis by scientists at the National Institutes of Health and George Washington University Medical Center, Washington, D.C. Findings were published July 3 in the New England Journal of Medicine. https://medicalxpress.com/news/2014-07-acute-kidney-injury-chronic-disease.html Diseases, Conditions, Syndromes Wed, 02 Jul 2014 17:00:03 EDT news323529337 More than one quarter of children with two copies of a high-risk variant in a specific group of genes develop an early sign of celiac disease called celiac disease autoimmunity (CDA) by age 5. The findings are from The Environmental Determinants of Diabetes in Youth consortium, or TEDDY . The National Institutes of Health-funded study, published July 2 in the New England Journal of Medicine, also found that participants in Sweden had higher rates of celiac disease than participants in the United States, Finland and Germany, even with the same genetic risks. https://medicalxpress.com/news/2014-07-gene-confers-percent-chance-early.html Diseases, Conditions, Syndromes Wed, 02 Jul 2014 17:00:01 EDT news323529400 Adults stop anti-rejection drugs after stem-cell transplant reverses sickle cell disease NIH trial success suggests a new treatment option for older, sicker patients https://medicalxpress.com/news/2014-07-adults-anti-rejection-drugs-stem-cell-transplant.html Medical research Tue, 01 Jul 2014 16:00:01 EDT news323439972 People with type 1 diabetes who used a bionic pancreas instead of manually monitoring glucose using fingerstick tests and delivering insulin using a pump were more likely to have blood glucose levels consistently within the normal range, with fewer dangerous lows or highs. The full report of the findings, funded by the National Institutes of Health, can be found online June 15 in the New England Journal of Medicine. https://medicalxpress.com/news/2014-06-bionic-pancreas-outperforms-insulin-adults.html Diabetes Mon, 16 Jun 2014 02:10:49 EDT news322103383 Long-term use of a drug combination reduces the risk of recurrent urinary tract infection by up to 80 percent in children with the urinary condition vesicoureteral reflux compared to placebo, according to research funded by the National Institutes of Health. Results were published online May 4 in the New England Journal of Medicine to coincide with presentation at the Pediatric Academic Societies Annual Meeting in Vancouver, British Columbia. https://medicalxpress.com/news/2014-05-drug-pair-children-urinary-infections.html Diseases, Conditions, Syndromes Sun, 04 May 2014 05:41:42 EDT news318400887 Even with more prescriptions for growth hormone, children and adolescents with chronic kidney disease were less likely to grow to normal height ranges if they came from lower-income families, according to research funded by the National Institutes of Health. Results from the Chronic Kidney Disease in Children (CKiD) Study are published in the December issue of the American Journal of Kidney Diseases and online today. https://medicalxpress.com/news/2013-11-growth-stunted-lower-income-youth-kidney.html Diseases, Conditions, Syndromes Thu, 21 Nov 2013 09:54:02 EST news304249982 Researchers have begun the first definitive, large-scale clinical trial to investigate if a vitamin D supplement helps prevent or delay type 2 diabetes in adults who have prediabetes, who are at high risk for developing type 2. Funded by the National Institutes of Health, the study is taking place at about 20 study sites across the United States. https://medicalxpress.com/news/2013-10-large-vitamin-d-diabetes.html Diabetes Tue, 22 Oct 2013 11:05:04 EDT news301658692 Researchers at the National Institutes of Health have created and confirmed the accuracy of a mathematical model that predicts how weight and body fat in children respond to adjustments in diet and physical activity. The results will appear online July 30 in The Lancet Diabetes and Endocrinology. https://medicalxpress.com/news/2013-07-math-effects-diet-physical-childhood.html Health Mon, 29 Jul 2013 18:30:01 EDT news294327171