https://phys.org/ en-us Latest news from Indiana University School of Medicine Between 2015 and 2019, excessive alcohol use resulted in over 140,000 deaths and 3.6 million years of potential life lost annually in the United States, making it the fourth leading cause of preventable death in the country. Despite these staggering numbers, only 4%—approximately 1.4 million people—received treatment for their condition. https://medicalxpress.com/news/2024-08-effective-screening-intervention-unhealthy-alcohol.html Addiction Wed, 14 Aug 2024 13:36:02 EDT news642861357 Indiana University School of Medicine researchers have made significant progress in understanding how cells communicate during inflammation. The study, recently published in Proceedings of the National Academy of Sciences, was conducted over a period of five years and focused on the molecules that enable cells to function during inflammation, particularly in the central nervous system where diseases like multiple sclerosis occur. https://medicalxpress.com/news/2024-08-inflammation-impacts-cell-communication.html Immunology Wed, 14 Aug 2024 13:18:03 EDT news642860281 An Indiana University School of Medicine physician scientist is making strides in understanding the molecular origins of fatty liver disease, a leading cause of liver failure in the United States. By identifying the critical role the urea cycle plays in its development, his findings could pave the way for new medications to treat this currently incurable disease. https://medicalxpress.com/news/2024-08-explores-urea-strong-fatty-liver.html Gastroenterology Tue, 13 Aug 2024 16:20:34 EDT news642784831 Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center have completed the most extensive mapping of healthy breast cells to date. These findings offer an important tool for researchers at IU and beyond to understand how breast cancer develops and the differences in breast tissue among genetic ancestries. https://medicalxpress.com/news/2024-08-comprehensive-atlas-breast-cells-tool.html Oncology & Cancer Mon, 12 Aug 2024 13:03:04 EDT news642686581 Indiana University School of Medicine researchers have made a significant breakthrough in developing a new gene therapy approach that restores full-length dystrophin protein, which could lead to new treatments for people with Duchenne muscular dystrophy (DMD). https://medicalxpress.com/news/2024-07-gene-therapy-approach-duchenne-muscular.html Genetics Thu, 25 Jul 2024 09:37:04 EDT news641119022 Nearly 3% of all children in the United States are diagnosed with autism, according to the Centers for Disease Control and Prevention. But a collaborative team of researchers at Indiana University and Purdue University are finding ways to make the right diagnosis sooner. https://medicalxpress.com/news/2024-05-eye-tracking-techniques-primary-autism.html Autism spectrum disorders Fri, 31 May 2024 16:04:16 EDT news636390251 Researchers have discovered a protein marker to help identify cells able to repopulate in patients with damaged blood vessels. Their findings, recently published in Circulation, could lead to new therapies for people with endothelial dysfunction, a type of disorder that contributes to coronary artery disease that may occlude with plaque and lack ability to carry sufficient blood into the heart tissue causing a heart attack. https://medicalxpress.com/news/2024-05-biomarker-cells-blood-vessels.html Cardiology Tue, 07 May 2024 16:47:22 EDT news634319237 A new study led by Indiana University School of Medicine researchers has found that a brain network condition called "explosive synchronization" could be the cause of extreme pain crises in people with sickle cell disease. https://medicalxpress.com/news/2024-04-brain-network-condition-painful-vaso.html Diseases, Conditions, Syndromes Wed, 24 Apr 2024 15:16:52 EDT news633190609 More than 90% of people with Down syndrome, the most common chromosomal disorder in humans and the most frequent genetic cause of intellectual disability, are diagnosed with Alzheimer's disease by ages 55–60. https://medicalxpress.com/news/2024-03-high-resolution-images-reveal-similarities.html Diseases, Conditions, Syndromes Fri, 29 Mar 2024 13:34:03 EDT news630938041 Black patients in need of a heart transplant may be less likely to receive one than white patients, according to a new study led by Indiana University School of Medicine researchers. https://medicalxpress.com/news/2024-03-black-men-heart-transplant-white.html Surgery Mon, 25 Mar 2024 17:01:05 EDT news630604862 A team of researchers led by Indiana University School of Medicine faculty have developed a breakthrough new blood test for schizophrenia, a psychiatric disorder that includes hallucinations and delusions. https://medicalxpress.com/news/2024-02-team-blood-psychosis-effective-treatments.html Psychology & Psychiatry Thu, 08 Feb 2024 13:04:03 EST news626619841 Since its introduction to the public in November 2022, ChatGPT, an artificial intelligence system, has substantially grown in use, creating written stories, graphics, art, and more with just a short prompt from the user. But when it comes to scientific, peer-reviewed research, could the tool be useful? https://medicalxpress.com/news/2024-02-artificial-intelligence-medical-articles.html Medical research Tue, 06 Feb 2024 16:37:03 EST news626459821 Indiana University School of Medicine researchers have uncovered vital insights regarding a liver trigger that blocks an undesired immune response from gene therapy, surprisingly resulting in activating specific immune cells despite the liver's typical role in suppressing immune responses. https://medicalxpress.com/news/2023-12-reveal-uncharted-liver-focused-pathway-gene.html Genetics Thu, 07 Dec 2023 17:10:08 EST news621191401 Indiana University researchers are collaborating on a novel approach to use neuroimaging and network modeling tools—previously developed to analyze the brains of patients in the clinic—to investigate Alzheimer's disease progression in preclinical animal models. https://medicalxpress.com/news/2023-11-brain-network-tools-advance-alzheimer.html Neuroscience Thu, 30 Nov 2023 15:02:35 EST news620578947 A study led by experts from Indiana University School of Medicine has shed new light on the genetic underpinnings of Alzheimer's disease. The team's research, rooted in human genetics studies, has unearthed a critical mutation within a key gene operating in the brain's immune cells, potentially elevating the risk of Alzheimer's disease. https://medicalxpress.com/news/2023-09-gene-mutation-alzheimer-disease.html Genetics Wed, 06 Sep 2023 12:59:24 EDT news613223961 A new multi-site study led by Indiana University School of Medicine has found increasing pediatric readiness in emergency departments reduces but does not eliminate racial and ethnic disparities in children and adolescents with acute medical emergencies. https://medicalxpress.com/news/2023-09-health-equity-important-aspect-quality.html Pediatrics Tue, 05 Sep 2023 17:22:04 EDT news613153321 Researchers from Indiana University School of Medicine have discovered a neglected brain region that could play a critical role in how likely a person with drug use disorders is to relapse, even after a long withdrawal period. Their findings were published recently in Biological Psychiatry. https://medicalxpress.com/news/2023-08-overlooked-brain-play-critical-role.html Neuroscience Thu, 24 Aug 2023 16:59:03 EDT news612115141 A new study by Indiana University School of Medicine researchers uses more genetically diverse mouse models to study the accumulation and spread of abnormal tau protein deposits in the brain—a known sign of Alzheimer's disease and several other neurodegenerative diseases. The study's findings, recently published in the Journal of Experimental Medicine, could lead to better research models that improve understanding of how different genetic backgrounds influence neurodegenerative disease development and treatment needs. https://medicalxpress.com/news/2023-08-neuroscientists-resource-alzheimer-disease.html Alzheimer's disease & dementia Tue, 22 Aug 2023 15:51:25 EDT news611938274 Researchers from Indiana University School of Medicine have diagnosed a Sumatran Orangutan at the Indianapolis Zoo with a rare genetic disease called Alkaptonuria. This is the first time the disease has been confirmed molecularly in a primate other than a human. https://phys.org/news/2023-07-indianapolis-zoo-orangutan-rare-genetic.html Veterinary medicine Thu, 27 Jul 2023 12:24:20 EDT news609679448 An estimated 16 million people in the United States have alcohol use disorders (AUDs), according to the National Institutes on Alcohol Abuse and Alcoholism (NIAAA). Now, Indiana University researchers have made a substantial discovery about the role genes play in the development of AUDs, finding that alteration of a group of genes known to influence neuronal plasticity and pain perceptions, rather than single gene defect, is linked to AUDs. https://medicalxpress.com/news/2023-07-gene-group-pain-brain-communication.html Genetics Mon, 17 Jul 2023 16:04:04 EDT news608828641 You may have heard it said before that a picture is worth a thousand words, but what about an emoji? https://medicalxpress.com/news/2023-06-emoji-physician-communicate.html Health Tue, 13 Jun 2023 12:54:04 EDT news605879640 Researchers at Indiana University School of Medicine have discovered alternative gene splicing, which occurs during gene expression, can impact a person's risk of alcohol use disorder (AUD). They recently published their findings in Molecular Psychiatry. https://medicalxpress.com/news/2023-05-link-alternative-gene-splicing-alcohol.html Genetics Tue, 30 May 2023 12:49:03 EDT news604669742 Indiana University School of Medicine researchers studying clonal hematopoiesis of indeterminate potential (CHIP), a blood condition that may increase the risk of blood cancer, discovered that obesity was strongly associated with the condition. Their findings were recently published in the Journal of Clinical Investigation. https://medicalxpress.com/news/2023-05-link-obesity-blood-cancer.html Oncology & Cancer Tue, 16 May 2023 01:48:35 EDT news603420503 While trying to understand what initiates breast cells to become cancerous, researchers at the Vera Bradley Foundation Center for Breast Cancer Research at Indiana University Melvin and Bren Simon Comprehensive Cancer Center have identified a new target for breast cancer treatment. https://medicalxpress.com/news/2023-04-cancer-breast-therapy.html Oncology & Cancer Thu, 20 Apr 2023 15:45:03 EDT news601224301 Alcohol-associated liver disease (ALD), a complex disorder that occurs in some patients who have engaged in excessive alcohol use, is one of the leading causes of chronic liver disease among veterans and liver transplant patients in the United States. Despite its prevalence, and despite many recent advances in the hepatology field, no new treatment interventions for ALD have been developed over the past several decades. https://medicalxpress.com/news/2023-04-protein-alcohol-associated-liver-disease.html Medical research Wed, 19 Apr 2023 04:16:24 EDT news601096580 Indiana University Melvin and Bren Simon Comprehensive Cancer Center served as the lead site for a promising first-in-human clinical trial for patients with relapsed multiple myeloma. Patients treated with higher doses of the immunotherapy called REGN5459 resulted in a 90.5% overall response rate. https://medicalxpress.com/news/2023-04-in-human-multiple-myeloma-response.html Oncology & Cancer Mon, 17 Apr 2023 16:53:16 EDT news600969193 For centuries, people have suspected a full moon in the sky to cause mysterious changes in people. Now, psychiatrists at Indiana University School of Medicine have found deaths by suicide increase during the full moon. https://medicalxpress.com/news/2023-04-deaths-suicide-significantly-week-full.html Medical research Fri, 07 Apr 2023 11:27:03 EDT news600085621 People with non-alcoholic fatty liver disease (NAFLD) may process certain medications less effectively due to significantly decreased levels of an important enzyme, according to a new study from Indiana University School of Medicine. A team of researchers led by Nick Powell, PharmD, and Naga Chalasani, MD, published their findings in the article "Clinically important alterations in pharmacogene expression in histologically severe nonalcoholic fatty liver disease" in the journal Nature Communications in March. https://medicalxpress.com/news/2023-04-people-nafld-decreased-liver-enzyme.html Medications Thu, 06 Apr 2023 11:38:02 EDT news599999881 A study by Indiana University School of Medicine researchers sheds new light on the development and treatment of a rare form of muscular dystrophy. The study's findings were recently published in Nature Communications. https://medicalxpress.com/news/2023-04-protein-bves-important-role-muscular.html Genetics Wed, 05 Apr 2023 15:39:32 EDT news599927969 Indiana University School of Medicine researchers have identified a promising new combination of drugs to treat juvenile myelomonocytic leukemia (JMML), a rare form of blood cancer that affects children. The group's findings were recently published in Molecular Therapy. https://medicalxpress.com/news/2023-04-uncover-drug-combination-rare-pediatric.html Medications Wed, 05 Apr 2023 14:42:04 EDT news599924521