https://phys.org/ en-us Phys.org internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. Histone variants help establish DNA methylation at transposons (jumping genes) while preventing this epigenetic modification from spreading to essential genes in plants, a study from the Institute of Science Tokyo reveals. By revealing how these chromosome-associated proteins guide the formation of precise epigenomic patterns, the findings provide new insights into the selective silencing of transposons, laying the groundwork for future epigenome-editing technologies for crop improvement and disease research. https://phys.org/news/2026-08-silence-genes-essential.html Plants & Animals Mon, 17 Aug 2026 16:40:03 EDT news706189934 Humans love dogs, but petting them can leave some people sneezing and wheezing. About 15% of the world's population lives with a dog allergy, which can increase the risk of hay fever and asthma. The main culprit is Can f 1, a protein found mainly in dog saliva. Right now, staying away from furry friends or getting regular immunotherapy shots or tablets is the only way to deal with the symptoms. https://phys.org/news/2026-08-gene-beagles-major-dog-allergen.html Biotechnology Sun, 16 Aug 2026 14:00:01 EDT news705919142 Like a delivery driver navigating crowded city streets, a gene-therapy-toting lipid nanoparticle faces a gauntlet of potential detours on its journey toward a cell's nucleus. First, there's entering the cell's plasma membrane; then navigating around organelles like the Golgi apparatus, mitochondria and endoplasmic reticulum—all destinations that can errantly absorb the particle's payload, rendering it ineffective at best or harmful at worst. And that's all before the particle even enters the nucleus and successfully makes a genetic change. https://phys.org/news/2026-08-crispr-roadblocks-scientists-genes-blocking.html Cell & Microbiology Thu, 13 Aug 2026 13:00:03 EDT news705841141 When a wound does not heal properly, it leaves a scar. Similarly, mutations—which are permanent changes to genetic code—are often the result of damaged DNA that has not been properly repaired. Mutations can impede the function of genes and lead to disease and aging, but they are also the source of genetic variation, which allows new traits to emerge and facilitates the evolutionary process. Scientists still do not fully understand why some damaged DNA segments are successfully repaired while others are not. https://phys.org/news/2026-08-dna-enzymes-favor-specific-sequences.html Molecular & Computational biology Mon, 10 Aug 2026 18:40:03 EDT news705595382 In a world first, scientists led by a team from Stanford University have created 16 viable viruses that do not exist in nature and were designed by AI. Their experiment, which is published in Science, could help in the fight against superbugs by allowing researchers to design customized viruses to kill drug-resistant bacteria. Thomas Inglesby and Moritz S. Hanke have published a Perspective piece on the work and its implications in the same edition of the journal. https://phys.org/news/2026-08-sixteen-ai-viruses-route-drug.html Cell & Microbiology Mon, 10 Aug 2026 07:00:01 EDT news705314814 Scientists at the Department of Energy's Oak Ridge National Laboratory have created a platform that pinpoints genetic triggers that turn microbes into efficient factories for new chemicals and materials. The method enables rapid, precise reprogramming of bacteria as biotechnology tools, supporting domestic production of valuable products and recovery of critical minerals and materials to enhance the nation's supply chains and global competitiveness. https://phys.org/news/2026-08-platform-bacterial-gene-biotech.html Cell & Microbiology Fri, 07 Aug 2026 15:00:01 EDT news705323281 When a virus enters a cell, its top priority is to replicate its genome rapidly, creating new viruses to infect elsewhere. The host has the opposite priority: to destroy the virus, ideally before it can do any harm. Biology has evolved diverse tactics for viral recognition and destruction, but they share a common theme—sensing that an invading viral genome is present in a cell. https://phys.org/news/2026-07-bacteria-virus-dna.html Cell & Microbiology Thu, 30 Jul 2026 18:20:02 EDT news704620612 Scientists have found a genetic switch that could shave years off avocado breeding by allowing researchers to identify one of a young tree's most important traits long before it flowers. https://phys.org/news/2026-07-gene-discovery-years-avocado.html Molecular & Computational biology Wed, 29 Jul 2026 08:40:04 EDT news704532781 Gene editing is a highly precise and powerful technology that allows scientists to insert, delete, modify or replace DNA bases in living organisms. It has a variety of uses, including correcting disease-causing mutations and improving crops. Tools like CRISPR act as molecular scissors that target specific places in a genome to make these changes. But the technology is not perfect and can accidentally edit the wrong pieces of DNA or RNA. https://phys.org/news/2026-07-ai-tiny-gene-editor-unintended.html Biotechnology Mon, 27 Jul 2026 13:38:56 EDT news704378300 The way to make a plant grow more may be to take something away. Trimming a section off a plant gene raised rice harvests by up to 25% in new tests by University of Chicago scientists. The plants also showed a better tolerance for drought and heat. https://phys.org/news/2026-07-trimming-rice-genes-boosts-yields.html Biotechnology Mon, 27 Jul 2026 09:00:08 EDT news704361541 When scientists want to create a protein that can potentially treat disease, one approach is to begin with a different protein and evolve it in the lab, selecting over many generations for versions with a new, desired function. https://phys.org/news/2026-07-combining-ai-protein-laboratory-evolution.html Biotechnology Fri, 24 Jul 2026 10:40:01 EDT news704105143 Researchers at King Abdullah University of Science and Technology (KAUST) have developed a new way to add large pieces of genetic information to plants, overcoming a challenge that has limited plant biotechnology for decades. The advance could help scientists build more complex traits into plants in the future, supporting research into areas such as crop resilience, sustainable agriculture, biotechnology and the use of plants as scalable platforms for producing therapeutics and biologics. https://phys.org/news/2026-07-genome-tool-large-genetic-sequences.html Biotechnology Wed, 22 Jul 2026 19:40:01 EDT news703949461 Scientists have successfully edited the genome of biting midges, opening the door to new research on how these insects transmit disease. Culicoides biting midges are small blood-feeding insects responsible for spreading important vector-borne viruses such as bluetongue virus (BTV), Schmallenberg virus (SBV) and epizootic hemorrhagic disease virus (EHDV), which cause major losses to livestock production worldwide. Despite their importance as disease vectors, Culicoides are among the smallest blood-feeding insects, just 1–4 mm (0.04–0.16 inches) long, making them difficult to study in the laboratory. https://phys.org/news/2026-07-world-gene-culicoides-midges-door.html Biotechnology Mon, 20 Jul 2026 13:40:12 EDT news703771621 Blood transfusions are crucial in human and veterinary medicine, yet human blood reserves are in constant need of donors, while blood bank systems in veterinary care are nearly nonexistent. This leaves canine transfusions largely reliant on donations from healthy dogs, but securing compatible blood remains a major challenge because dogs also have different blood types. https://phys.org/news/2026-07-generating-red-blood-cell-cells.html Biotechnology Sun, 19 Jul 2026 20:00:05 EDT news703496702 Scientists have made many advances using traditional CRISPR technology, especially in medicine, but they are now seeking ways to create genuinely new gene-editing enzymes with properties that have not already evolved naturally. A new study, published in Science, describes a new AI-designed synthetic TnpB enzyme, called SynTnpBs, that has outperformed the natural reference enzyme. https://phys.org/news/2026-07-aidesigned-geneediting-enzymes-crispr-toolbox.html Biotechnology Fri, 17 Jul 2026 12:59:19 EDT news703511930 Cadmium (Cd) contamination poses a serious threat to global food safety. As a toxic and carcinogenic heavy metal, cadmium can accumulate in agricultural soils through industrialization and urbanization before entering the human food chain. Rice is especially vulnerable because it absorbs more cadmium than other major cereal crops, making it one of the largest dietary sources of cadmium exposure for nearly half the world's population. https://phys.org/news/2026-07-tiny-gene-cadmium-rice-yields.html Biotechnology Thu, 16 Jul 2026 08:20:03 EDT news703405327 A team led by bioengineers at the University of California San Diego has developed a genome-scale reference map that details how individual genes control the functions and identities of human stem cells. This open-access resource could help researchers build virtual cell models for complex diseases, as well as design patient-specific treatments for these diseases. https://phys.org/news/2026-07-million-stem-cells-reveal-genome.html Biotechnology Mon, 13 Jul 2026 10:30:01 EDT news703155590 Researchers at the Center for Crop and Food Innovation (CCFI) have made a significant contribution to a landmark study, uncovering tens of thousands of previously hidden structural variations influencing agriculturally important traits in the mung bean. The study, published today in Nature Genetics, presents the world's first graph-based pan-genome for the pulse crop, offering a comprehensive resource for understanding the genetic basis of key agronomic traits and accelerating crop improvement. https://phys.org/news/2026-07-genetic-secrets-mung-bean-crops.html Molecular & Computational biology Fri, 10 Jul 2026 12:20:03 EDT news702896259 RNA has emerged as one of the most promising molecules in modern medicine, enabling advances from mRNA vaccines and gene therapies to genome editing and synthetic biology. However, designing RNA molecules that reliably fold into a desired secondary structure remains a major challenge. Even for relatively short sequences, the number of possible nucleotide combinations grows exponentially, making it difficult to identify optimal candidates. As a result, conventional computational methods often require extensive candidate evaluations, creating a significant bottleneck when experimental validation is both time-consuming and costly. https://phys.org/news/2026-07-optimizing-rna-ai-ising-machine.html Biotechnology Wed, 08 Jul 2026 14:50:01 EDT news702724633 Researchers have spent decades—and billions of dollars—sequencing animal and crop genomes, but fungi have historically been the forgotten middle child of genomics, only noticed when they're ruining bread or colonizing toes. https://phys.org/news/2026-07-fungal-genome-tool-fresh-paths.html Biotechnology Fri, 03 Jul 2026 09:40:03 EDT news702287408 All living organisms are known to inherit genes, DNA sequences that contain instructions for producing specific proteins and performing biological functions, from their parents. In some cases, however, genes can also shift between different species via a process known as horizontal gene transfer (HGT). https://phys.org/news/2026-07-holoparasitic-genes-host-dna-survive.html Evolution Thu, 02 Jul 2026 10:20:01 EDT news702204647 Every time a cell copies its DNA, parts of the genome are exposed and vulnerable to damage or errors. Molecular biologist Simon Boulton is interested in how cells spot and repair damage to their DNA, and what happens if this process fails or if key genes are mutated. https://phys.org/news/2026-06-loss-dna-protector-gene-exposes.html Cell & Microbiology Tue, 30 Jun 2026 18:40:03 EDT news702043381 Reactive oxygen species (ROS) produced naturally during cellular metabolism often cause oxidative damage to cells. However, these molecules also play an important role in normal cellular signaling. While ROS are established as essential signaling molecules in various organisms, their precise role in basic plant development and morphogenesis remains unclear. https://phys.org/news/2026-06-ros-enzymes-cell-division-tissue.html Plants & Animals Fri, 26 Jun 2026 16:20:01 EDT news701700481 Genome editing lets scientists rewrite DNA, the instruction manual inside every living cell, with a precision that was unthinkable a generation ago. Technologies such as CRISPR have made this almost routine, and its uses now reach far beyond medicine, from engineering hardier crops and more productive microbes to creating sustainable biomaterials. https://phys.org/news/2026-06-cleanfinder-browser-based-genome-analysis.html Biotechnology Wed, 24 Jun 2026 17:20:09 EDT news701528761 A lot of things need to go right on a molecular level for immune cells to launch an adaptive response to an infection. B cells can produce different classes of antibodies tailored for specific infections through controlled DNA damage and repair that alter the genetic information needed to encode the antibodies. When the process goes awry, it can produce mutations or genomic rearrangements that promote the formation of tumors. https://phys.org/news/2026-06-real-imaging-reveals-rna-hub.html Cell & Microbiology Tue, 23 Jun 2026 17:00:02 EDT news701445781 Gene editing of plant DNA has the potential to produce crops with increased performance and resilience, but it can take a long time to achieve these gains. To shorten this process, scientists often use screening tools to determine where and how edits to the plant genome can be most effective. https://phys.org/news/2026-06-leaf-based-fluorescence-gene.html Biotechnology Mon, 22 Jun 2026 19:40:03 EDT news701362681 In a rapidly changing climate landscape, the plants we rely on for food, textiles and more face a multitude of challenges, including rising temperatures, drought and disease. Caltech's Gözde Demirer, the Clare Boothe Luce Assistant Professor of Chemical Engineering, uses genetic engineering tools to make crops more resilient to such threats and enhance plant health. Now, she and a team of Caltech researchers have found a new solution to an old problem in an unlikely source: the zebra finch. https://phys.org/news/2026-06-bird-derived-gene-tool-inserts.html Biotechnology Mon, 22 Jun 2026 18:30:06 EDT news701368321 A team of researchers led by Professor Akitsu Hotta (Department of Clinical Application) developed a comprehensive framework that combines computational prediction, experimental validation and whole-genome analysis to evaluate intended and unintended mutations arising from CRISPR-Cas9 delivered by lipid nanoparticles (LNPs), providing a practical strategy to improve the safety of genome-editing therapies. The work is published in the journal Molecular Therapy Nucleic Acids. https://phys.org/news/2026-06-crispr-safety-unintended-mutations.html Biotechnology Mon, 22 Jun 2026 13:20:10 EDT news701352362 Prime editing can potentially repair the vast majority of known disease-causing human mutations, but the technology, first developed in 2019, has not yet been widely used in the body, or in vivo, to treat genetic disease. The only clinical application of prime editing that has been publicly announced uses the technology to edit cells outside the body before transplanting them back into the patient. https://phys.org/news/2026-06-scientists-aspect-prime-closer-genetic.html Biotechnology Mon, 15 Jun 2026 12:40:04 EDT news700736907 Rapidly intensifying global climate instability is causing increasingly erratic temperature fluctuations. When sudden cold snaps strike during a crop's critical flowering window, they trigger irreversible pollen abortion, slashing yields of staple crops by 20% to 60%. Passive defenses offer minimal protection at a high cost, while breeding for continuous cold resistance often backfires by wasting vital energy under normal temperatures. Shifting the breeding paradigm toward "on-demand" climate resilience—maintaining high yields in favorable seasons while securing stable performance under stress—is critical. https://phys.org/news/2026-06-cold-crops-demand-climate-resilience.html Molecular & Computational biology Wed, 10 Jun 2026 17:40:04 EDT news700321081