https://phys.org/ en-us Phys.org internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. Scientists at the Department of Energy's Oak Ridge National Laboratory have created a platform that pinpoints genetic triggers that turn microbes into efficient factories for new chemicals and materials. The method enables rapid, precise reprogramming of bacteria as biotechnology tools, supporting domestic production of valuable products and recovery of critical minerals and materials to enhance the nation's supply chains and global competitiveness. https://phys.org/news/2026-08-platform-bacterial-gene-biotech.html Cell & Microbiology Fri, 07 Aug 2026 15:00:01 EDT news705323281 When a virus enters a cell, its top priority is to replicate its genome rapidly, creating new viruses to infect elsewhere. The host has the opposite priority: to destroy the virus, ideally before it can do any harm. Biology has evolved diverse tactics for viral recognition and destruction, but they share a common theme—sensing that an invading viral genome is present in a cell. https://phys.org/news/2026-07-bacteria-virus-dna.html Cell & Microbiology Thu, 30 Jul 2026 18:20:02 EDT news704620612 Gene editing is a highly precise and powerful technology that allows scientists to insert, delete, modify or replace DNA bases in living organisms. It has a variety of uses, including correcting disease-causing mutations and improving crops. Tools like CRISPR act as molecular scissors that target specific places in a genome to make these changes. But the technology is not perfect and can accidentally edit the wrong pieces of DNA or RNA. https://phys.org/news/2026-07-ai-tiny-gene-editor-unintended.html Biotechnology Mon, 27 Jul 2026 13:38:56 EDT news704378300 Researchers at Queen Mary University of London and University of Cambridge in collaboration with colleagues at HHMI Janelia and NIH, have created some of the most detailed three-dimensional maps ever generated of human airway cells, revealing how the specialized cells that protect our lungs are built and organized. https://phys.org/news/2026-07-3d-nanoscale-human-airway-epithelium.html Bio & Medicine Thu, 23 Jul 2026 15:50:01 EDT news704038861 Researchers at King Abdullah University of Science and Technology (KAUST) have developed a new way to add large pieces of genetic information to plants, overcoming a challenge that has limited plant biotechnology for decades. The advance could help scientists build more complex traits into plants in the future, supporting research into areas such as crop resilience, sustainable agriculture, biotechnology and the use of plants as scalable platforms for producing therapeutics and biologics. https://phys.org/news/2026-07-genome-tool-large-genetic-sequences.html Biotechnology Wed, 22 Jul 2026 19:40:01 EDT news703949461 Bacteria have spent decades evolving resistance to virtually every antibiotic we have thrown at them. To stay ahead, new drugs must hit targets that existing antibiotics have never touched. A research team at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) has now developed a series of synthetic drug candidates that do exactly that: By blocking an essential molecular supply system, these molecules cut off the bacteria's supply of essential vitamins and starve them to death. The team published its findings in two studies in the Journal of Medicinal Chemistry. https://phys.org/news/2026-07-antibiotic-candidates-starve-resistant-bacteria.html Biochemistry Tue, 21 Jul 2026 16:00:05 EDT news703858081 Scientists have successfully edited the genome of biting midges, opening the door to new research on how these insects transmit disease. Culicoides biting midges are small blood-feeding insects responsible for spreading important vector-borne viruses such as bluetongue virus (BTV), Schmallenberg virus (SBV) and epizootic hemorrhagic disease virus (EHDV), which cause major losses to livestock production worldwide. Despite their importance as disease vectors, Culicoides are among the smallest blood-feeding insects, just 1–4 mm (0.04–0.16 inches) long, making them difficult to study in the laboratory. https://phys.org/news/2026-07-world-gene-culicoides-midges-door.html Biotechnology Mon, 20 Jul 2026 13:40:12 EDT news703771621 Blood transfusions are crucial in human and veterinary medicine, yet human blood reserves are in constant need of donors, while blood bank systems in veterinary care are nearly nonexistent. This leaves canine transfusions largely reliant on donations from healthy dogs, but securing compatible blood remains a major challenge because dogs also have different blood types. https://phys.org/news/2026-07-generating-red-blood-cell-cells.html Biotechnology Sun, 19 Jul 2026 20:00:05 EDT news703496702 Scientists have made many advances using traditional CRISPR technology, especially in medicine, but they are now seeking ways to create genuinely new gene-editing enzymes with properties that have not already evolved naturally. A new study, published in Science, describes a new AI-designed synthetic TnpB enzyme, called SynTnpBs, that has outperformed the natural reference enzyme. https://phys.org/news/2026-07-aidesigned-geneediting-enzymes-crispr-toolbox.html Biotechnology Fri, 17 Jul 2026 12:59:19 EDT news703511930 Researchers from Heinrich Heine University Düsseldorf (HHU) and Kiel University (CAU) have examined immune system function in an early-branching animal—a sea anemone. They discovered that the immune systems of these animals can selectively distinguish between different microorganisms, protecting beneficial bacteria from harmful bacteria—an ability that has been attributed only to vertebrates to date. So-called "nematosomes" play an important role in this process. https://phys.org/news/2026-07-invertebrates-distinguish-good-bad-bacteria.html Ecology Thu, 16 Jul 2026 14:20:11 EDT news703417988 A team led by bioengineers at the University of California San Diego has developed a genome-scale reference map that details how individual genes control the functions and identities of human stem cells. This open-access resource could help researchers build virtual cell models for complex diseases, as well as design patient-specific treatments for these diseases. https://phys.org/news/2026-07-million-stem-cells-reveal-genome.html Biotechnology Mon, 13 Jul 2026 10:30:01 EDT news703155590 The molecular machinery that normally builds proteins inside cells has now taken on a new role as a "switch." A research team at POSTECH (Pohang University of Science and Technology) has developed a new 'RNA-based smart gene circuit' platform that can simultaneously read multiple signals inside a cell, make its own decisions and autonomously generate programmed responses. This represents a step beyond simple genetic manipulation toward an era in which cells themselves function as "living computers." https://phys.org/news/2026-07-ribosome-based-gene-circuit-cells.html Biochemistry Sat, 11 Jul 2026 15:00:06 EDT news702647029 The speed at which a cell produces proteins is a decisive factor in determining whether it divides, specializes or retains its stem cell properties. A team of researchers led by Professor Stefan H. Stricker, professor of epigenetic engineering at LMU's Biomedical Center and research group leader at Helmholtz Munich, has worked with international partners to demonstrate directly for the first time that the amount of ribosomal RNA (rRNA) directly regulates these processes. Their results were published in the journal Science. https://phys.org/news/2026-07-crispr-method-protein-production-cells.html Biotechnology Wed, 08 Jul 2026 16:00:01 EDT news702729337 A new genetic screening method allows researchers to efficiently modulate individual genes across entire tissues and provides new insights into human development. The research, published in eLife, is described as a landmark study by the journal's editors. They go on to say in their assessment of the work that "this technical tour de force is exceptional and one of the first studies to reveal new knowledge on human development through embryo models." https://phys.org/news/2026-07-unveils-genetic-screen-human.html Biotechnology Tue, 07 Jul 2026 14:20:11 EDT news702646951 Researchers have spent decades—and billions of dollars—sequencing animal and crop genomes, but fungi have historically been the forgotten middle child of genomics, only noticed when they're ruining bread or colonizing toes. https://phys.org/news/2026-07-fungal-genome-tool-fresh-paths.html Biotechnology Fri, 03 Jul 2026 09:40:03 EDT news702287408 The reefs scattered throughout the tropics arose only after algae took up full-time residence in coral cells, supplying corals with abundant food and enabling them to build extensive shallow-water communities. But with warming oceans, algae are often abandoning coral—causing what's known as bleaching—and turning reefs that were once teeming with life into ghost towns. https://phys.org/news/2026-07-algae-coral-reefs-hijacking-cells.html Ecology Wed, 01 Jul 2026 11:00:01 EDT news702115922 Every time a cell copies its DNA, parts of the genome are exposed and vulnerable to damage or errors. Molecular biologist Simon Boulton is interested in how cells spot and repair damage to their DNA, and what happens if this process fails or if key genes are mutated. https://phys.org/news/2026-06-loss-dna-protector-gene-exposes.html Cell & Microbiology Tue, 30 Jun 2026 18:40:03 EDT news702043381 A research team at the University of Turku in Finland has developed a reliable laboratory model to study BAP1-deficient melanomas, which are a rare type of melanoma that evade the immune system once they have metastasized and are universally resistant to current state-of-the-art immunotherapies. The tool could change how therapies are developed for aggressive melanomas that currently have almost no effective treatment options. https://phys.org/news/2026-06-cellular-rare-deadly-melanomas-enables.html Cell & Microbiology Mon, 29 Jun 2026 18:00:08 EDT news701958121 Reactive oxygen species (ROS) produced naturally during cellular metabolism often cause oxidative damage to cells. However, these molecules also play an important role in normal cellular signaling. While ROS are established as essential signaling molecules in various organisms, their precise role in basic plant development and morphogenesis remains unclear. https://phys.org/news/2026-06-ros-enzymes-cell-division-tissue.html Plants & Animals Fri, 26 Jun 2026 16:20:01 EDT news701700481 A new study has uncovered a previously unknown antiviral defense mechanism in sea anemones, revealing that animals may have evolved more than one way to fight viral infections. Researchers discovered that a protein resembling a key component of the human immune system actually plays the opposite role, yet remains essential for effective antiviral protection. https://phys.org/news/2026-06-sea-anemones-reveal-antiviral-defense.html Evolution Fri, 26 Jun 2026 05:00:08 EDT news701592181 Genome editing lets scientists rewrite DNA, the instruction manual inside every living cell, with a precision that was unthinkable a generation ago. Technologies such as CRISPR have made this almost routine, and its uses now reach far beyond medicine, from engineering hardier crops and more productive microbes to creating sustainable biomaterials. https://phys.org/news/2026-06-cleanfinder-browser-based-genome-analysis.html Biotechnology Wed, 24 Jun 2026 17:20:09 EDT news701528761 Gene editing of plant DNA has the potential to produce crops with increased performance and resilience, but it can take a long time to achieve these gains. To shorten this process, scientists often use screening tools to determine where and how edits to the plant genome can be most effective. https://phys.org/news/2026-06-leaf-based-fluorescence-gene.html Biotechnology Mon, 22 Jun 2026 19:40:03 EDT news701362681 In a rapidly changing climate landscape, the plants we rely on for food, textiles and more face a multitude of challenges, including rising temperatures, drought and disease. Caltech's Gözde Demirer, the Clare Boothe Luce Assistant Professor of Chemical Engineering, uses genetic engineering tools to make crops more resilient to such threats and enhance plant health. Now, she and a team of Caltech researchers have found a new solution to an old problem in an unlikely source: the zebra finch. https://phys.org/news/2026-06-bird-derived-gene-tool-inserts.html Biotechnology Mon, 22 Jun 2026 18:30:06 EDT news701368321 A team of researchers led by Professor Akitsu Hotta (Department of Clinical Application) developed a comprehensive framework that combines computational prediction, experimental validation and whole-genome analysis to evaluate intended and unintended mutations arising from CRISPR-Cas9 delivered by lipid nanoparticles (LNPs), providing a practical strategy to improve the safety of genome-editing therapies. The work is published in the journal Molecular Therapy Nucleic Acids. https://phys.org/news/2026-06-crispr-safety-unintended-mutations.html Biotechnology Mon, 22 Jun 2026 13:20:10 EDT news701352362 Every year, hundreds of millions of tons of petrochemical-based plastics are produced, much of which ends up in the environment or is incinerated. This exacerbates greenhouse gas emissions and the environmental crisis caused by plastic pollution. Now, a study led by the University of Barcelona has produced a biodegradable bioplastic of high industrial value—polyhydroxybutyrate, or PHB—from unprocessed potato starch in a single 24-hour step, a strategic breakthrough that could help reduce dependence on oil and the volume of persistent plastic waste. https://phys.org/news/2026-06-bacterium-potato-starch-biodegradable-plastic.html Cell & Microbiology Fri, 12 Jun 2026 12:20:09 EDT news700478881 Researchers from Skoltech—a VEB.RF group institution—and their colleagues from the U.S. and China have explained how the antibiotic resistance gene established itself in the genome of the bacterium Klebsiella pneumoniae. The findings could help control this widespread microbe, which can cause pneumonia, meningitis and other, often hospital-acquired, infections in patients with weakened immunity. The findings were reported in the Proceedings of the National Academy of Sciences. https://phys.org/news/2026-06-anti-crispr-proteins-hospital-infections.html Cell & Microbiology Wed, 10 Jun 2026 16:00:03 EDT news700314481 Similar to the way DNA damage can contribute to human diseases such as cancer, it can also disrupt growth, development and survival in plants. Every day, plants endure environmental stresses such as sunlight, radiation, drought and soil stress—all of which can damage their DNA. However, they cannot move away from danger. How do plants handle all that damage? https://phys.org/news/2026-06-survive-constant-dna-newly-protein.html Molecular & Computational biology Mon, 08 Jun 2026 19:30:01 EDT news700157401 Rice is a staple food for nearly half the global population and an important dietary source of magnesium, a mineral essential for human health, plant growth and energy metabolism. Although magnesium is known to influence grain quality and taste, the biological mechanism controlling how the mineral reaches rice grains has remained largely unknown. https://phys.org/news/2026-06-magnesium-discovery-rice-nutrition.html Molecular & Computational biology Mon, 08 Jun 2026 18:10:01 EDT news700156741 IS110 transposons are a large, diverse family of bacterial insertion sequences (IS elements)—small, mobile DNA elements that can move from one genomic location to another. They have recently attracted broad interest due to the finding that some of these transposons use a bridge RNA (bRNA) to recognize both donor DNA and target DNA. https://phys.org/news/2026-06-rna-transposon-mechanics-figure-intermediate.html Cell & Microbiology Fri, 05 Jun 2026 13:40:08 EDT news699882121 A team of researchers led by Luigi Naldini at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) has developed a new strategy to significantly improve the precision and safety of CRISPR-Cas9 gene editing in human blood stem cells, potentially overcoming one of the major barriers limiting broader clinical application of genome editing therapies. https://phys.org/news/2026-06-smart-platform-gene-hematopoietic-stem.html Cell & Microbiology Mon, 01 Jun 2026 11:07:13 EDT news699530761