New tools to study bioactive lipids

NAEs are bioactive lipid molecules that appear to play roles in energy balance, inflammation, stress responses and addiction. How NAE levels are regulated and their precise contributions to biological processes remain poorly ...

To find giant black holes, start with Jupiter

The revolution in our understanding of the night sky and our place in the universe began when we transitioned from using the naked eye to a telescope in 1609. Four centuries later, scientists are experiencing a similar transition ...

Studying cells in reduced dimensions

Single-cell RNA sequencing is a powerful tool for identifying transcriptomic variations and developmental trajectories in cell types that determine the course of diseases like cancer, with the goal of eventually improving ...

Probing DNA damage repair

Cells missing the protein HMCES are hypersensitive to DNA-damaging agents that cause a common type of DNA lesion—an "abasic" site. But the agents also generate other types of lesions associated with mutations and cell lethality, ...

Staph's activation of blood clotting

Acute bacterial endocarditis—infection of the inner lining of the heart—is most often caused by the bacteria Staphylococcus aureus ("staph") and has up to a 40% mortality rate.

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