Reinforcement learning: From board games to protein design

Scientists have successfully applied reinforcement learning to a challenge in molecular biology. The team of researchers developed powerful new protein design software adapted from a strategy proven adept at board games like ...

SpyLigation technology uses light to switch on proteins

Scientists can now use light to activate protein functions both inside and outside of living cells. The new method, called light-activated SpyLigation, can turn on proteins that are normally off to allow researchers to study ...

Signaling proteins shown to play key role in tuberculosis biology

A set of 10 signaling proteins found in the microbe that causes tuberculosis (TB) play a far larger role in regulating the bacterium's growth, development and behavior than previously thought, according to recent research. ...

Bat virus receptor studies vital to predict spillover risk

New research shows that the closest bat virus relatives of the human Middle-East Respiratory Syndrome (MERS) coronavirus efficiently bind to bat ACE2 receptors as an entry point into these cells. These receptors have some ...

Beyond AlphaFold: AI excels at creating new proteins

Over the past two years, machine learning has revolutionized protein structure prediction. Now, three papers in Science describe a similar revolution in protein design.

Cilia-free stem cells offer new path to study rare diseases

A group of rare diseases called "ciliopathies"—polycystic kidney disease notable among them—emerge from defects in cilia, the tiny hair-like structures on the surface of almost every cell type. But the specific molecular-level ...

Scientists set out to map the world's genomic diversity

An international consortium of scientists has launched a new effort to create a reference genome that captures the genetic diversity of all the peoples of the world. The researchers describe the initiative, called the Human ...

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