The Wistar Institute is a biomedical center, with a focus on cancer research and vaccine development. It is located in the University City section of Philadelphia, Pa. Founded in 1892 as the first independent, nonprofit, biomedical research institute in the country, Wistar has held the Cancer Center designation from the National Cancer Institute since 1972. Wistar has more than thirty laboratories, which are home to three research programs: a gene expression and regulation program, a molecular and cellular oncogenesis program, and an immunology program. The Institute's research program on cancer includes the following goals and areas: Wistar's training and outreach initiatives include: The Wistar Institute was founded in 1892 as the nation’s first independent medical research facility. It is named for Caspar Wistar, M.D., a prominent Philadelphia physician who began his medical practice in 1787. Dr. Wistar was the author of the first American anatomy textbook. To augment his medical lectures and illustrate comparative anatomy, Dr. Wistar began a collection of dried, wax-injected, and preserved human specimens.
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Long segments of RNA—encoded in our DNA but not translated into protein—are key to physically manipulating DNA in order to activate certain genes, say researchers at The Wistar Institute. These non-coding RNA-activators ...
Cell & Microbiology
Feb 17, 2013
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Researchers at The Wistar Institute have uncovered new aspects of the three-dimensional organization of the genome, specifically how the genetic material is compacted and de-compacted in a timely fashion during the different ...
Cell & Microbiology
Oct 9, 2017
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Cellular senescence is a state in which normal healthy cells do not have the ability to divide. Senescence can occur when cancer-causing genes are activated in normal cells or when chemotherapy is used on cancer cells. Thus, ...
Cell & Microbiology
Oct 31, 2016
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A team of researchers from Philadelphia and Norway has determined the structure of an enzyme complex that modifies one end of most human proteins and is made at elevated levels in numerous forms of cancer. A study in Nature ...
Cell & Microbiology
Aug 4, 2013
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Chromosomes are responsible for carrying our genes and essentially protecting the information that helps ensure normal, healthy growth, with vital instructions being passed on from cell to cell by a process known as mitosis. ...
Cell & Microbiology
Aug 6, 2015
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Chromosomes - long, linear DNA molecules – are capped at their ends with special DNA structures called telomeres and an assortment of proteins, which together act as a protective sheath. Telomeres are maintained through ...
Cell & Microbiology
Nov 21, 2012
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A team of scientists from The Wistar Institute in Philadelphia and the Peter MacCallum Cancer Center in Melbourne, Australia, discovered a new checkpoint mechanism that fine-tunes gene transcription. As reported in a study ...
Molecular & Computational biology
May 17, 2021
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RNA, once considered a bit player in the grand scheme by which genes encode protein, is increasingly seen to have a major role in human genetics. In a study presented in the April 25 issue of the journal Cell, researchers ...
Cell & Microbiology
May 1, 2013
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Researchers at The Wistar Institute have discovered a new enzymatic function of the Epstein-Barr Virus (EBV) protein EBNA1, a critical factor in EBV's ability to transform human cells and cause cancer. Published in Cell, ...
Cell & Microbiology
Jan 21, 2021
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A new study by researchers at The Wistar Institute, an international biomedical research leader in cancer, immunology, infectious disease, and vaccine development, has identified a new potential pathway for developing therapeutics ...
Cell & Microbiology
Jan 19, 2022
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