Scientists at St. Jude Children's Research Hospital have demonstrated how drug makers can avoid two key problems: toxicity and resistance. The researchers made slight changes to a small molecule to reduce its metabolism and ...
Biochemistry
Feb 28, 2023
0
73
St. Jude Children's Research Hospital scientists solved the 3D structure of a major protein complex in cilia, signaling appendages found on cells. The structure was captured at the highest resolution to date. The work serves ...
Cell & Microbiology
Feb 13, 2023
0
54
CTCF is a critical protein known to play various roles in key biological processes such as transcription. Scientists at St. Jude Children's Research Hospital have used a next-generation protein degradation technology to study ...
Biotechnology
Jan 25, 2023
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22
Cryogenic (frozen) protein structures are central to understanding function and developing drugs. Scientists at St. Jude Children's Research Hospital have created an algorithm to reveal when freezing the proteins may create ...
Biochemistry
Jun 7, 2022
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72
Scientists at St. Jude Children's Research Hospital are studying voltage-gated ion channels (VGICs). Their work revealed a previously unknown mechanism of inactivation for one such channel that plays an important role in ...
Cell & Microbiology
May 20, 2022
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90
Scientists at St. Jude Children's Research Hospital and Columbia University/New York State Psychiatric Institute are studying G protein-coupled receptors (GPCRs), membrane proteins that are the target of one-third of approved ...
Cell & Microbiology
Apr 27, 2022
0
24
Apoptosis is a process that causes cell death. It can go awry in cancer cells, sustaining the disease. Scientists at St. Jude Children's Research Hospital have captured the structure of BAK, a protein that triggers apoptosis. ...
Cell & Microbiology
Jan 11, 2022
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91
Immunologists at St. Jude Children's Research Hospital have identified biochemical "switches" that control development of regulatory T cells and offer a novel strategy for treatment of autoimmune diseases and cancer. The ...
Cell & Microbiology
Dec 29, 2021
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287
CTCF is a transcription factor that has been a research target due to its role in regulating a critical oncogene called MYC. Scientists at St. Jude Children's Research Hospital have found direct evidence that CTCF governs ...
Cell & Microbiology
Sep 7, 2021
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39
About 95% of all crystal structures obtained for various proteins and deposited in public databases are captured using cryogenic technology. This technology requires frozen conditions. Scientists at St. Jude Children's Research ...
Biochemistry
Aug 19, 2021
0
419
