St. Jude scientist Vibhor Mishra, Ph.D., is homing in on the location where important processes in gene regulation occur, and where single-stranded transcripts are converted into double-stranded RNAs (dsRNAs).
Cell & Microbiology
Jul 28, 2021
0
8
Scientists at St. Jude Children's Research Hospital are studying liquid-liquid phase separation (LLPS), a biophysical process through which proteins and nucleic acids in a cell are compartmentalized without a membrane. The ...
Biochemistry
Jul 26, 2021
0
240
St. Jude Children's Research Hospital scientists have used single-molecule fluorescence resonance energy transfer (smFRET) and cryogenic electron microscopy (cryo-EM) to capture six new structures of the ribosome and its ...
Molecular & Computational biology
Jul 8, 2021
0
14
St. Jude Children's Research Hospital scientists are studying the processes that enable cells to respond and adapt to environmental stress, many of which are also associated with neurodegenerative diseases. In complementary ...
Cell & Microbiology
Jun 25, 2021
1
18
Instruments, even expensive, high-tech ones like DNA sequencing machines, aren't perfect. Researchers use sequencers to decode the chemical bases that make up DNA, the blueprint of life. The devices play a key role in cancer ...
Biotechnology
Mar 18, 2021
0
0
Scientists at St. Jude Children's Research Hospital have developed an easy to use, sensitive and high-throughput method to define sites of unintended double stranded breaks in DNA caused by genome editors like the CRISPR-Cas9 ...
Biotechnology
Jun 16, 2020
0
18
St. Jude Children's Research Hospital investigators are studying the details of how phase separation leads to the formation of RNA granules, assemblies of protein and RNA that are not bound by a membrane. Their findings show ...
Cell & Microbiology
Apr 17, 2020
0
133
St. Jude Children's Research Hospital scientists have identified a new therapeutic strategy that enhanced cancer immunotherapy, slowed tumor growth and extended the lives of mice with cancer. The research appears today in ...
Cell & Microbiology
Dec 12, 2019
0
370
Like a boat helping passengers cross a river, transporters move substances across cell membranes. This process is fundamental to the healthy functioning of cells in life forms from bacteria to humans. The function of these ...
Cell & Microbiology
Nov 13, 2019
0
108
July 15, 2019) Life depends on double-stranded DNA unwinding and separating into single strands that can be copied for cell division. St. Jude Children's Research Hospital scientists have determined at atomic resolution the ...
Molecular & Computational biology
Jul 15, 2019
1
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