Looping the genome—how cohesin does the trick

Twenty years ago, the protein complex cohesin was first described by researchers at the IMP. They found that its shape strikingly corresponds to its function: when a cell divides, the ring-shaped structure of cohesin keeps ...

How cells take out the trash—phosphoarginine deciphered

Cells never forget to take out the trash. It has long been known that cells tag proteins for degradation by labelling them with ubiquitin, a signal described as "the molecular kiss of death". Tim Clausen's group at the Research ...

Watching molecular machines at work

When one cell divides into two - that is how all forms of life are propagated - the newly born daughter cells have to be equipped with everything they will need in their tiny lives. Most important of all is that they inherit ...

Identifying brain regions automatically

Using the example of the fruit fly, a team of biologists led by Prof. Dr. Andrew Straw has identified patterns in the genetic activity of brain cells and taken them as a basis for drawing conclusions about the structure of ...

Cohesin molecule safeguards cell division

The cohesin molecule ensures the proper distribution of DNA during cell division. Scientists at the Research Institute of Molecular Pathology (IMP) in Vienna can now prove the concept of its carabiner-like function by visualizing ...

A molecular toolkit for gene silencing

The team of Johannes Zuber at the IMP in Vienna, Austria, managed to overcome remaining key limitations of RNA interference (RNAi) - a unique method to specifically shut off genes. By using an optimized design, the scientists ...

Pushing the limits of light microscopy

A team of researchers from the IMP Vienna together with collaborators from the Vienna University of Technology established a new microscopy technique which greatly enhances resolution in the third dimension. In a simple set-up, ...

A skeleton for chromosomes

Researchers at the IMP Vienna discovered that cohesin stabilizes DNA. Jan-Michael Peters and his team at the Research Institute of Molecular Pathology (IMP) found that the structure of Chromosomes is supported by a kind of ...

Scientists shed light on the 'dark matter' of DNA

In each cell, thousands of regulatory regions control which genes are active at any time. Scientists at the Research Institute of Molecular Pathology (IMP) in Vienna have developed a method that reliably detects these regions ...

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