New tool aids stem cell engineering for medical research

A Mayo Clinic researcher and his collaborators have developed an online analytic tool that will speed up and enhance the process of re-engineering cells for biomedical investigation. CellNet is a free-use Internet platform ...

Study finds role of Cul4 molecule in genome instability and cancer

Mayo Clinic researchers have shown that a molecule called Cul4 helps to deposit DNA-packaging histone proteins onto DNA, an integral step in cramming yards of genetic code into compact coils that can fit into each cell. When ...

How gold nanoparticles can help fight ovarian cancer

Positively charged gold nanoparticles are usually toxic to cells, but cancer cells somehow manage to avoid nanoparticle toxicity. Mayo Clinic researchers found out why, and determined how to make the nanoparticles effective ...

Researchers develop new sensor for methylated DNA

Collaborators from Mayo-Illinois Alliance for Technology Based Healthcare have developed a new, single molecule test for detecting methylated DNA. Methylation—the addition of a methyl group of molecules to a DNA strand—is ...

Researchers provide atomic view of a histone chaperone

Mayo Clinic researchers have gained insights into the function of a member of a family of specialized proteins called histone chaperones. Using nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography, they ...

Moving beyond embryonic stem cells: Encouragement on the horizon

For nearly two decades, the medical world and the American public have grappled with the lightning-rod topic of stem cells, in particular the controversy surrounding cells from human embryos. But when researchers four years ...

Researchers describe measles viral protein movement

Mayo Clinic researchers have shown that proteins on the surface of a cell twist a viral protein into position, allowing the virus to start infection and cause disease, all in a movement as graceful as a ballroom dance. The ...

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