The Max Planck Institute of Immunobiology and Epigenetics (MPI-IE) in Freiburg is an interdisciplinary research institution that conducts basic research in two key areas of modern biology. Immunobiology is concerned with the ways multicellular organisms defend themselves against pathogens. We study the evolutionary origins and the development of lymphoid organs and immune effector cells, the function of antigen receptors, and the genetic basis of host-pathogen interactions. This information underpins efforts to better diagnose and treat immunodeficiency and inflammatory diseases. Epigenetics is the study of inheritable traits that are not caused by changes in the underlying DNA sequence. Epigenetic mechanisms are crucial for the organization and utilization of our genetic information. Since the susceptibility to diseases can be promoted by epigenetic dysfunction, epigenetic research has far-reaching implications for diagnosis and therapy of human disease.

Address
Stuebeweg 51 79108 Freiburg Germany
Website
https://www.ie-freiburg.mpg.de/

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Secrets of thymus formation revealed

The thymus is a crucial organ of the immune system. In the thymus, the well-known T cells mature: As killer cells, they recognize and destroy virus-infected or malignant cells, and as so-called helper T cells they assist ...

A gel for dosage compensation

Human females have two X chromosomes, and males only one. This chromosome imbalance also extends to other branches of the animal kingdom. Interestingly, the humble fruit fly has devised a different way to 'equalize' these ...

Mothers ensure their offspring's success through epigenetics

Parents pass genes along to their offspring traits that equip them for life. In recent years, research has shown that the reality is much more complex and that parents endow much more than just genes. A new study in Cell ...