How cells learn to 'count'

One of the wonders of cell biology is its symmetry. Mammalian cells have one nucleus and one cell membrane, and most humans have 23 pairs of chromosomes. Trillions of mammalian cells achieve this uniformity—but some consistently ...

Nanocontainer ships titan-size gene therapies and drugs into cells

Scientists at Johns Hopkins Medicine report they have created a tiny, nanosize container that can slip inside cells and deliver protein-based medicines and gene therapies of any size—even hefty ones attached to the gene-editing ...

Finding a cell's true identity

Scientists have long sorted cells into different varieties based on their appearance under a microscope or, for differences that are more visually subtle, based on the behavior of a handful of genes. But in a bid to reveal ...

How DNA is read and copied

Two scientists at the Johns Hopkins University School of Medicine have unraveled aspects of how DNA organizes and preserves genetic information. Newly published research by Cynthia Wolberger, Ph.D., and James Berger, Ph.D., ...

Key acid-activated protein channel identified

Johns Hopkins researchers have discovered a long-sought protein, the proton-activated chloride channel (PAC), that is activated in acidic environments and could protect against the tissue-damaging effects of stroke, heart ...

Turning silenced cancer genes back into fighters

Working with human colon cancer cells and mice, researchers led by experts at the Johns Hopkins Kimmel Cancer Center say they have successfully blocked the activity of portions of a protein known as UHRF1 and restored the ...

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