True love: How transcription factors interact to create a heart

Scientists at the Gladstone Institutes have discovered that three transcription factors—proteins that direct gene expression—interact with each other and the genome to influence how a heart forms in an embryo. Without ...

Improving genome editing with drugs

One of the most exciting scientific advances made in recent years is CRISPR—the ability to precisely edit the genome of cells. However, although this method has incredible potential, the process is extremely inefficient. ...

Using viruses to find the cellular Achilles heel

Back-to-back studies from researchers at the Gladstone Institutes have exposed new battle tactics employed by two deadly viruses: hepatitis C (HCV) and the Kaposi's sarcoma-associated herpesvirus (KSHV). Published in the ...

Fast-mutating DNA sequences shape early development

What does it mean to be human? According to scientists the key lies, ultimately, in the billions of lines of genetic code that comprise the human genome. The problem, however, has been deciphering that code. But now, researchers ...

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