The Friedrich Miescher Institute for Biomedical Research (FMI) is part of the Novartis Research Foundation and is a world-class center for basic research in life sciences based in Basel, Switzerland. The FMI is devoted to the pursuit of fundamental biomedical research. Areas of expertise are: In these fields the FMI has gained international recognition as a center of excellence in innovative biomedical research. Research is carried out in 22 independent but highly interactive research teams. In addition, seven technology platforms, ranging from functional genomics to microscopy and imaging, support the research activities with cutting-edge technology. As of 2011, the institute counts 320 collaborators of which 90 are postgraduate students participating in the FMI International PhD Program, 100 are postdoctoral collaborators and 22 are research group leaders. Since 2004, the institute is led by Susan M. Gasser. in chronological order The FMI is an affiliated institute of the University of Basel. It provides biomedical research and career training for over 90 PhD students. FMI selects its highly international student body during a twice-yearly interview-based selection program.
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UV light damages the DNA of skin cells, which can lead to skin cancer. But this process is counteracted by DNA repair machinery, acting as a molecular sunscreen. It has been unclear, however, how repair proteins work on DNA ...
Molecular & Computational biology
May 30, 2019
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Interactions between RNA and proteins impact all aspects of RNA metabolism. These interactions are mediated by diverse RNA binding domains (RBDs), of which many remain to be discovered. One example of a recently identified ...
Cell & Microbiology
May 03, 2018
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21
Research groups led by Botond Roska at the Friedrich Miescher Institute for Biomedical Research (FMI) and Daniel Müller at the ETH Zurich Department of Biosystems Science and Engineering (D BSSE) have developed a novel method ...
Biotechnology
Dec 19, 2017
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36
Jeff Chao, Junior group leader at the FMI, and his group developed a sophisticated method to measure mRNA degradation in single cells. They developed a fluorescent biosensor that allows the distinction of intact transcripts ...
Cell & Microbiology
Oct 31, 2017
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14
Helge Grosshans and his group at the Friedrich Miescher Institute for Biomedical Research (FMI) have identified two distinct modes of transcription termination – one dependent on, and one independent of, the highly conserved ...
Cell & Microbiology
Oct 27, 2017
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3
Ishan Deshpande and his colleagues from the group of Susan Gasser and the Protein Structure Facility at the FMI elucidated the mechanism of how Mec1-Ddc2, a tumor suppressor involved in DNA damage response assembles at sites ...
Cell & Microbiology
Oct 16, 2017
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68
A novel approach developed at the Friedrich Miescher Institute for Biomedical Research (FMI) has allowed scientists in Dirk Schübeler's group to dissect and quantify the individual steps of transcription initiation. Unexpectedly, ...
Cell & Microbiology
Jul 26, 2017
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15
If cellular identity is to be maintained, it is important that actively transcribed chromatin stretches remain in a loose configuration as long as these genes are needed. Marc Bühler and his group have uncovered a novel ...
Cell & Microbiology
Jun 30, 2017
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96
All cells are confronted with DNA damage, for example by exposure of the skin to UV rays, chemical byproducts of nerve cells consuming sugar, or immune cells destroying bacteria. If these DNA lesions are not - or badly - ...
Cell & Microbiology
Jun 13, 2017
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183
Control of RNA lifespan is vital for the proper functioning of our cells. Marc Bühler's group at the Friedrich Miescher Institute for Biomedical Research (FMI) has discovered a novel mechanism determining the fate of RNA ...
Cell & Microbiology
Jun 05, 2017
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