Scientists and engineers have used uniform magnetic fields to drive iron-bearing nanoparticles to metal stents in injured blood vessels, where the particles deliver a drug payload that successfully prevents blockages in those ...
Bio & Medicine
Apr 19, 2010
1
0
A team of researchers at Children's Hospital of Philadelphia (CHOP) has characterized how the gut microbiome develops in the first hours of infancy, providing a critical baseline for how changes in this environment can impact ...
Cell & Microbiology
Apr 16, 2020
0
165
A research collaboration that combines novel "big-data" informatics tools with expertise in basic biology has uncovered details of an essential process in life: how a crucial enzyme locates the site on DNA where it begins ...
Cell & Microbiology
Mar 3, 2016
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15
Challenging the dogma of what scientists thought they understood about DNA viruses, a team of researchers led by Children's Hospital of Philadelphia (CHOP) has shown that adenovirus uses its own efficient RNA splicing mechanisms ...
Molecular & Computational biology
Oct 21, 2021
0
68
Making use of a new "super resolution" microscope that provides sharp images at extremely small scales, scientists have achieved unprecedented views of the immune system in action. The new tool, a stimulated emission depletion ...
Cell & Microbiology
Sep 13, 2011
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0
Class I major histocompatibility complex (MHC-I) proteins play an essential role in the immune system of all jawed vertebrates. The MHC-I displays peptide fragments of proteins from within the cell on the cell surface, "presenting" ...
Biochemistry
Jun 13, 2023
0
112
Researchers have discovered key mechanisms and structural details of a fundamental biological process—how a cell nucleus and its chromosomal material reorganizes itself after cell division. The new findings in chromosomal ...
Cell & Microbiology
Dec 4, 2019
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140
In exploring how proteins interact with crucial DNA sequences to regulate gene activity, researchers have shed light on key biological events that may eventually be manipulated to provide new disease treatments.
Cell & Microbiology
Jun 7, 2012
0
0
In a step forward in the development of genetic medicines, researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a proof-of-concept ...
Biotechnology
Jul 27, 2023
0
69
In a new study published in Nature Chemical Biology, researchers at Children's Hospital of Philadelphia (CHOP) have revealed the molecular mechanics of a cell-surface molecule that is a potential immunotherapy target. Using ...
Biochemistry
Jun 20, 2022
0
92
