Lipoproteins behave 'almost like a tiny Velcro ball'

Cholesterol carried in high-density lipoprotein particles, or HDL cholesterol, has been dubbed the good cholesterol, because people whose HDL levels are high have a lower risk of developing heart disease. That link was first ...

How do protein tangles get so long in Alzheimer's?

Early in the course of Alzheimer's disease—long before future patients begin to notice symptoms—neurofibrillary tangles composed of tau protein aggregates begin to form in their brain cells. How toxic these aggregates ...

A molecular look at nascent HDL formation

Oil and water don't mix. But our aqueous blood is full of different types of hydrophobic lipids—including cholesterol. In order to travel via the bloodstream, those lipids need to hitch a ride on an amphipathic carrier. ...

An RNA key that unlocks innate immunity

RNA has long been the neglected middle child of biomolecules, the go-between between DNA, which encodes the cell's instructions, and proteins, which carry them out. Increasingly, though, researchers are recognizing RNA as ...

Bacterial protein mimics DNA to sabotage cells' defenses

Infections with Salmonella bacteria, often caused by eating or handling undercooked meat or eggs, affect about 100 million people a year worldwide. The suffering the infection causes—abdominal cramps, fever and diarrhea—is ...

Building a flu factory from host cell components

Perhaps inspired by the annual 3 to 5 million cases of severe influenza worldwide, the Guinness World Record organization is advertising for individuals or organizations to attempt a record for the most people getting a flu ...

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