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Study links 'stuck' stem cells to hair turning gray

Study links “stuck” stem cells to hair turning gray
Hair-coloring stem cells (at left, in pink) need to be in the hair germ compartment in order to be activated (at right) to develop into pigment. Credit: Springer-Nature Publishing

Certain stem cells have a unique ability to move between growth compartments in hair follicles, but get stuck as people age and so lose their ability to mature and maintain hair color, a new study shows.

Led by researchers from NYU Grossman School of Medicine, the new work focused on cells in the skin of mice and also found in humans called melanocyte stem cells, or McSCs. Hair color is controlled by whether nonfunctional but continually multiplying pools of McSCs within hair follicles get the signal to become that make the protein pigments responsible for color.

Published in the journal Nature on April 19, the new study showed that McSCs are remarkably plastic. This means that during normal hair growth, such cells continually move back and forth on the maturity axis as they transit between compartments of the developing hair follicle. It is inside these compartments where McSCs are exposed to different levels of maturity-influencing protein signals.

Specifically, the research team found that McSCs transform between their most primitive stem cell state and the next stage of their maturation, the transit-amplifying state, depending on their location.

The researchers found that as hair ages, sheds and then repeatedly grows back, increasing numbers of McSCs get stuck in the stem cell compartment called the hair follicle bulge. There, they remain, do not mature into the transit-amplifying state and do not travel back to their original location in the germ compartment, where WNT proteins would have prodded them to regenerate into pigment cells.

"Our study adds to our basic understanding of how melanocyte stem cells work to color hair," said study lead investigator Qi Sun, Ph.D., a postdoctoral fellow at NYU Langone Health. "The newfound mechanisms raise the possibility that the same fixed-positioning of melanocyte stem cells may exist in humans. If so, it presents a potential pathway for reversing or preventing the graying of human hair by helping jammed cells to move again between developing hair follicle compartments."

Researchers say McSC plasticity is not present in other self-regenerating stem cells, such as those making up the hair follicle itself, which are known to move in only one direction along an established timeline as they mature. For example, transit-amplifying hair follicle cells never revert to their original stem cell state. This helps explain in part why hair can keep growing even while its pigmentation fails, says Sun.

Earlier work by the same research team at NYU showed that WNT signaling was needed to stimulate the McSCs to mature and produce pigment. That study had also shown that McSCs were many trillions of times less exposed to WNT signaling in the hair follicle bulge than in the hair germ compartment, which is situated directly below the bulge.

In the latest experiments in mice whose hair was physically aged by plucking and forced regrowth, the number of hair follicles with McSCs lodged in the follicle bulge increased from 15% before plucking to nearly half after forced aging. These cells remained incapable of regenerating or maturing into pigment-producing melanocytes.

The stuck McSCs, the researchers found, ceased their regenerative behavior as they were no longer exposed to much WNT signaling and hence their ability to produce pigment in new hair follicles, which continued to grow.

By contrast, other McSCs that continued to move back and forth between the follicle bulge and hair germ retained their ability to regenerate as McSCs, mature into melanocytes, and produce pigment over the entire study period of two years.

"It is the loss of chameleon-like function in melanocyte that may be responsible for graying and loss of ," said study senior investigator Mayumi Ito, Ph.D., a professor in the Ronald O. Perelman Department of Dermatology and the Department of Cell Biology at NYU Langone Health.

"These findings suggest that melanocyte stem cell motility and reversible differentiation are key to keeping hair healthy and colored," said Ito, who is also a professor in the Department of Cell Biology at NYU Langone.

Ito says the team has plans to investigate means of restoring motility of McSCs or of physically moving them back to their germ compartment, where they can produce pigment.

For the study, researchers used recent 3D-intravital-imaging and scRNA-seq techniques to track cells in almost real time as they aged and moved within each .

More information: Mayumi Ito, De-differentiation maintains melanocyte stem cells in a dynamic niche, Nature (2023). DOI: 10.1038/s41586-023-05960-6. www.nature.com/articles/s41586-023-05960-6

Carlos Galvan et al, Yo-yoing stem cells defy dogma to maintain hair colour, Nature (2023). DOI: 10.1038/d41586-023-00918-0 , www.nature.com/articles/d41586-023-00918-0

Journal information: Nature

Provided by NYU Langone Health

Citation: Study links 'stuck' stem cells to hair turning gray (2023, April 19) retrieved 24 May 2024 from https://phys.org/news/2023-04-links-stuck-stem-cells-hair.html
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