Replicating mangosteen peel extract as a treatment for intestinal inflammation in humans and animals

Replicating mangosteen peel extract, treatment for intestinal inflammation in humans and animals
Graphical abstract. Credit: Journal of Functional Foods (2021). DOI: 10.1016/j.jff.2021.104814

A group of researchers in Thailand has replicated "Hydroxy-xanthones," the antioxidant-rich vital extracts found in mangosteen peels that kill germs and halt infections in the intestinal mucosa.

Not only is mangosteen the queen of Thai fruits—a delicious and healthy fruit—but its peel is also abundant with beneficial extracts. Local wisdom deemed mangosteen peel a good treatment for upset stomachs, skin inflammation, and wounds. There have been efforts to apply mangosteen peel extracts to various medicines and products such as plasters, gels, and surgical masks.

Associate Professor Dr. Suthasinee Poonyachoti of the Department of Physiology, Faculty of Veterinary Science, Chulalongkorn University, Thailand, has recently been successful in developing a substance that replicates the chemical structure of mangosteen peel extract and that helps stall leakage in the intestine. Aside from its , the extract reduces the need for medication for both humans and animals.

Xanthones—a natural substance in the mangosteen peel rich with benefits

Research on mangosteen peel enabled Associate Professor Dr. Suthasinee to discover xanthones, a substance in the flavanol group that is effective in combatting or halting various types of inflammation with anti-cancer, anti-bacterial, anti-allergy, anti-inflammatory, anti-microbial, anti-malarial and anti-oxidant qualities.

To investigate xanthones' ability to reduce inflammation and destroy bacteria, a research project in collaboration with the Faculty of Medicine, Srinakharinwirot University, Thailand, was launched. The project aims to develop and extract xanthones in the form of hydroxyxanthones or HDX with the highest efficacy for the health of humans and animals.

"Extractions of mangosteen peels have brought about a variety of substances both beneficial and harmful. Moreover, they must go through a rather complicated process and we cannot control the quality of the extracts since it is dependent upon factors such as planting methods, use of fertilizer, climate, and care," Associate Professor Dr. Suthasinee explained.

"We chose the method of analysis and sought to mimic the chemical structure of xanthones from mangosteen peels, giving us the desired essential extracts which are easier to apply directly as part of adjuvants in medicines, foods, and other products and to control their efficacy in the best manner possible."

Leaky gut syndrome—a cause of disease in both humans and animals

Leaky gut syndrome can lead to many diseases, especially septicemia that can be hidden in . This happens when there is an abnormality in the functions of the intestines and the microvilli.

"If you can imagine how the cells in the microvilli work—they line up next to each other and are responsible for screening and controlling , and bacteria that enter the bloodstream. When inflammation occurs, the cells cannot line up next to each other and function like a fortress, which makes it possible for toxic or foreign substances to enter the bloodstream. The condition is dangerous and must be treated before it is too late," she explained.

A does not always show any symptoms or if it does it could affect other physical ailments such as overtiredness, fatigue, headaches, or other body aches without any clear indication of the causes.

"The cause is not clear but hypothesized to be the result of stress. If the symptom occurs in human beings, they can consult physicians right away. However, if this occurs in animals, it is harder to tell if they are sick."

Developing HDX into health products for humans and animals

This research is at the experimental stage to determine the quality of HDX's performance. It has been used in pig farms first before being experimented on human beings and larger and more diverse types of animals. As Associate Professor Dr. Suthasinee concluded, "In the future, HDX will experiment in adjuvants in a variety of products like medicines and to improve the quality of life of both humans and animals."

The research was published in the Journal of Functional Foods.

More information: Wannaporn Chayalak et al, Hydroxyxanthone ameliorates IL1β-induced epithelial barrier disruption in colonic-like cells by down-regulation of p-MLC expression, Journal of Functional Foods (2021). DOI: 10.1016/j.jff.2021.104814

Journal information: Journal of Functional Foods

Provided by ResearchSEA

Citation: Replicating mangosteen peel extract as a treatment for intestinal inflammation in humans and animals (2022, September 5) retrieved 1 December 2022 from
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