Researchers find hybrid metabolism in fermented food microbe

Researchers Find Hybrid Metabolism in Fermented Food Microbe
Researchers find a previously unknown energy metabolism in lactic acid bacteria species that could lead to healthier, tastier fermented foods. Credit: Karen Wang-Diggs

Lactic acid bacteria are essential in creating fermented foods like yogurt, cheese and sauerkraut. Certain strains are also used as probiotics to improve human gut health.

Researchers at the University of California, Davis, and Rice University have discovered that use a previously unknown energy metabolism, which radically changes the of how these bacteria may thrive in their .

Researchers found the species Lactiplantibacillus plantarum uses a hybrid metabolism, which combines features of respiration with fermentation.

"Using this blended metabolism, lactic acid bacteria like L. plantarum grow better and do a faster job acidifying its environment," said co-corresponding author Maria Marco, a professor in the and technology department with the UC Davis College of Agricultural and Environmental Sciences.

The findings, published in the journal eLIFE, could lead to new technologies that use lactic acid bacteria to produce healthier and tastier fermented foods and beverages in ways which also minimize food waste. Manipulating this metabolism could change the flavor and texture of fermented foods.

"We may also find that this blended metabolism has benefits in other habitats, such as the digestive tract," Marco said. "The ability to manipulate it could improve gut health."

A puzzling beginning

The study began with a puzzle. Unlike fermentation, respiration requires an external molecule that can accept electrons, like oxygen in aerobic respiration. Some microorganisms that mainly gain energy by respiration can use electron acceptors located outside the cell. This ability, called extracellular electron transfer, has been tied to . A newly identified set of extracellular electron transfer genes were found throughout lactic acid bacteria, which use fermentation metabolism for energy conservation and growth.

"It was like finding the metabolic genes for a snake in a whale," said co-corresponding author Caroline Ajo-Franklin, a bioscientist with Rice University. "It didn't make a lot of sense, and we thought, 'We've got to figure this out.'"

The common bacteria they studied, L. plantarum, depends predominantly on fermentation. "But when we put them under particular circumstances where we're providing them with a that makes it harder to make lactate, the main end-product made during fermentation, they've got to do some workarounds. That's when the new metabolism kicks in," Ajo-Franklin said.

According to Marco, "This blended metabolism allows L. plantarum to overcome major bottlenecks in growth by allowing the bacteria to send electrons outside of the cell."

The research team showed how showed how L. plantarum uses this metabolism to change its environment in a food fermentation. Triggering this pathway with electrodes also offers many possibilities for fine-tuning food fermentations to change how they taste.

More information: Sara Tejedor-Sanz et al, Extracellular electron transfer increases fermentation in lactic acid bacteria via a hybrid metabolism, eLife (2021) DOI: 10.7554/eLife.70684

Journal information: eLife

Provided by UC Davis

Citation: Researchers find hybrid metabolism in fermented food microbe (2022, February 14) retrieved 19 April 2024 from
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