Promising advances in breast regeneration therapy

Promising advances in breast regeneration therapy
Mini-breast with blood vessels and a photo taken 3 months after transplantation. Credit: Osaka University

A team of researchers from Osaka University, Kyoto Prefectural University of Medicine, and Toppan Printing Co., Ltd. succeeded in reconstructing adipose tissue balls ("mini-breasts") with a functional vascular network using patient-derived cells, achieving a high graft survival rate in small animal models.

So far, were primarily used in breast reconstruction following mastectomy. In Japan, the breast implant manufactured by Allergan was the only product approved by the Ministry of Health, Labour and Welfare. In July 2019, however, the U.S. Food and Drug Administration (FDA) requested Allergan to recall its due to risk of breast implant-associated (BIA-ALCL), and their production was discontinued.

Although autologous tissue-based breast reconstruction, in which the patient's fat cells are collected and injected, has also been performed, the graft survival rate is low and outcomes vary with the patient's background. Some patients have to undergo several transplant surgeries.

In this study, the research team used type I collagen microfibers (CMFs) and applied their unique tissue engineering technique to the production of mini-breasts. CMFs act as a scaffold for adipocytes, adipose-derived , and vascular endothelial cells. The fabricated vascular network supplies the cells with nutrients and oxygen, and connection between the mini-breast and the patient's blood vessels was also established. Transplanting this mini-breast into small animals resulted in a graft survival rate twice as high as that of conventional aspirated fat tissue transplantation.

Since derived from patients are used, no inflammatory reaction was observed, indicating that the mini-breasts are highly safe. Furthermore, the volume of the mini-breast to be implanted is adjustable by in vitro culture. "Our findings will lead to a new, highly safe regenerative medicine that can replace the conventional fat cell injection and implantation," says Prof. Matsusaki, who lead the study.

The technique used in this study was introduced in "3-D collagen microfibers stimulate the functionality of preadipocytes and maintain the phenotype of mature adipocytes for long term cultures," published in Acta Biomaterialia.


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More information: Fiona Louis et al. 3D collagen microfibers stimulate the functionality of preadipocytes and maintain the phenotype of mature adipocytes for long term cultures, Acta Biomaterialia (2018). DOI: 10.1016/j.actbio.2018.11.048
Journal information: Acta Biomaterialia

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