Researchers develop 'lab on a chip' for personalized drug efficacy monitoring

Researchers develop ‘lab on a chip’ for personalized drug efficacy monitoring
Credit: University of California, Irvine

UCI researchers and collaborators have developed a "lab on a chip" platform to facilitate continuous, inexpensive, rapid and personalized drug screening. The technology is capable of evaluating the effectiveness of treatments on cancer cells without bulky readout equipment or requiring the shipment of samples to labs. The scientists' work is the subject of a new study published in the America Chemical Society journal Analytical Chemistry.

"There is an ever-present need for simplified and low-cost identification of a patient's personal cancer resistance and medication efficacy before and throughout treatment," said senior author Rahim Esfandyarpour, UCI assistant professor of electrical engineering & computer science, as well as biomedical engineering. "We envision our work as another step toward potentially enabling the personalized screening of drug efficacy on individual patients' samples, possibly leading us to a better understanding of drug resistance and the optimization of patients' treatments." He said that most current approaches to drug efficacy testing require expensive imaging, lab work and large-scale cell culture experiments.

"Our platform is an initial prototype that we hope to further develop in the future into a personalized medicine tool for facing ," said co-author Vanessa Velasco, a Stanford University postdoctoral researcher. The lab-on-a-chip technology employs advanced electrical and electrochemical techniques to precisely manipulate of interest in parallel with the continuous characterization of the potential effectiveness of therapeutic agents custom-made for patients. The end result should greatly reduce the time and cost associated with treating cancer.

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More information: Vanessa Velasco et al. Personalized Drug Efficacy Monitoring Chip, Analytical Chemistry (2019). DOI: 10.1021/acs.analchem.9b03291
Journal information: Analytical Chemistry

Citation: Researchers develop 'lab on a chip' for personalized drug efficacy monitoring (2019, November 22) retrieved 24 May 2022 from
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