Researchers grow cells in 'paper organs'

Long before scientists test new medicines in animals or people, they study the effects of the substances on cells growing in Petri dishes. However, a 2-D layer of cells is a poor substitute for the much more complex 3-D structure of tissues in organs. Now, researchers reporting in the ACS journal Nano Letters have used a 3-D printer to make paper organs, complete with artificial blood vessels, that they can populate with cells.

In the body, tissues with similar functions are grouped together in organs, such as the brain, heart or stomach. Organs also contain supporting cells, including nerves, blood vessels and connective tissues. An organ's 3-D architecture provides biological, structural and mechanical support to cells that influences how they grow and respond to external stimuli, such as medicines. Yu Shrike Zhang and colleagues wanted to see whether they could combine 3-D printing and to make supports for artificial organs that they could then fill with cells. Cellulose, a polysaccharide made by plants, algae and some bacteria, is a low-cost material used to make .

To create a breast tumor model, the researchers 3-D printed petroleum jelly-paraffin ink into a bacterial cellulose hydrogel. Then, they air-dried the hydrogel so that it became porous and paper-like. When they heated the ink, it liquefied and was easy to remove, leaving behind hollow microchannels. The team wet the paper "organ" and added endothelial cells—the cell type that lines —to the microchannels, and added breast cancer to the rest of the structure.

Dried paper organs can be stored for long periods of time and then rehydrated to produce inexpensive tissue models, which could be useful for drug screening and personalized medicine, the researchers say.


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More information: Feng Cheng et al. Generation of Cost-Effective Paper-Based Tissue Models through Matrix-Assisted Sacrificial 3D Printing, Nano Letters (2019). DOI: 10.1021/acs.nanolett.9b00583
Journal information: Nano Letters

Citation: Researchers grow cells in 'paper organs' (2019, May 1) retrieved 22 July 2019 from https://phys.org/news/2019-05-cells-paper.html
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