Ecologist dissects the science of de-extinction

Ecologist dissects the science of de-extinction
Beth Shapiro (center) poses with genetics professors Nancy Manley and Douglas Menke. Shapiro, a UGA alumna and evolutionary biologist at UC Santa Cruz, returned to campus April 4 to deliver the Boyd Lecture. Credit: Amy Ware

Spoiler alert: It is not possible to clone a wooly mammoth

This information undoubtedly will disappoint "Jurassic Park" fans, but it comes from an expert—Beth Shapiro, the UGA alumna and who wrote the book "How to Clone a Mammoth: The Science of De-Extinction." Shapiro returned to campus April 4 to deliver the George H. Boyd Distinguished Lecture.

During her talk, "Can—and Should—Technology Reverse Extinction?," Shapiro introduced the audience to the field of ancient DNA and outlined the science required to bring a species back from extinction. Essentially, researchers can't clone a if they don't have access to a living woolly mammoth.

"It is not possible to bring back mammoths, or passenger pigeons, or Neanderthals, or Adolf Hitler, or the dodo, or sabre-toothed cats, dinosaurs, the thylacine, the great auk, the Carolina parakeet, or the gastric brooding frog," said Shapiro, professor of ecology and at the University of California, Santa Cruz; Howard Hughes Medical Institute investigator; and 2009 MacArthur Fellow.

If she had her choice, though, she'd bring back the gastric brooding frog. They became extinct in the mid-1980s, but gastric brooding frogs swallowed fertilized eggs and six weeks later barfed up fully formed frogs.

"That's freaking awesome," she said.

Though the woolly mammoth will remain extinct, technological advances make it possible for scientists to create a genetic match for a living creature—your dog, for example. But it would not actually be your dog, according to Shapiro.

"We and everything else are much more than the sequence of the As and Cs and Gs and Ts that make up the code of our DNA," she said.

That same technology—a targeted gene editing tool known as CRISPR—may, however, be useful in helping species that are in danger of becoming extinct. CRISPR allows scientists to search for a genetic sequence and replace it with a sequence from another animal or even another species.

"As we're facing an extinction crisis, and climates and habitats are changing too fast for evolution to keep up, these technologies may be something that we can do to try and save some of these things from becoming extinct," she said.

The black-footed ferret, for example, was thought to be extinct until a population was discovered in the mid-1980s. They were bred successfully in captivity, but died of sylvatic plague when released into their habitat.

Scientists are hoping to stage a "genetic rescue" by increasing diversity—and resilience—in the population using genetic sequences from two black-footed ferrets collected prior to the population crash by the Frozen Zoo in San Diego. A similar strategy worked for the American chestnut tree, which survived fungal blight after researchers introduced a blight-resistant gene from wheat.

Humans have been altering DNA sequences for as long as we've existed, Shapiro noted.

"It's just that these technologies are making these things that we normally do over many thousands of years in trial and error much easier to do," she said.

The field is young, and scientists can't know all the potential consequences ahead of time, but Shapiro believes the potential benefit of genetic rescue is worth the risk.

"I would argue, looking at the 20,000 species that are in danger of becoming extinct within the next several decades, it's far riskier not to think about these technologies, to allow the science to develop," she said. "It's far riskier not to do that, because we're going to lose all of this."

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