Diabetes impairs multipotent stromal cell antibacterial activity

March 4, 2019, Mary Ann Liebert, Inc
Credit: Mary Ann Liebert, Inc., publishers

A new study reveals that the multipotent stromal cells (MSCs) of persons with diabetes have diminished capacity to fight off bacterial infection, providing new understanding into the basis of diabetes-associated immune dysfunction. The research is published in Stem Cells and Development.

Zijun Zhang and colleagues from the Orthobiologic Laboratory at MedStar Union Memorial Hospital, Baltimore, MD, present their work in an article titled "Compromised Antibacterial Function of Multipotent Stromal Cells in Diabetes". To identify this diminished antibacterial activity, the authors isolated MSCs from the bone marrow of diabetic and non-diabetic donors and tested the effects of the cells' supernatants on bacterial growth. The authors also showed that the co-culture of diabetes-associated MSCs with macrophages inhibits bacterial phagocytosis, and additional experiments addressed the and cytokine production responsible for these effects.

"Given the proposed use of MSCs as a therapeutic strategy in the treatment of diabetes, the careful consideration of the implications of these data for this and other are highly recommended," says Editor-in-Chief Graham C. Parker, Ph.D., The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI.

Explore further: Stem cells can differentiate into neurons and may be useful post-stroke therapeutics

More information: Young Cho et al, Compromised Antibacterial Function of Multipotent Stromal Cells in Diabetes, Stem Cells and Development (2018). DOI: 10.1089/scd.2018.0219

Related Stories

MicroRNAs identified as novel targets for treating asthma

June 24, 2016

A new study shows that microRNAs, which are small, noncoding RNA molecules that can silence genes, have an important role in inducing asthma. Regulating the function of specific miRNAs identified in the study could represent ...

Recommended for you

Coffee-based colloids for direct solar absorption

March 22, 2019

Solar energy is one of the most promising resources to help reduce fossil fuel consumption and mitigate greenhouse gas emissions to power a sustainable future. Devices presently in use to convert solar energy into thermal ...

NASA instruments image fireball over Bering Sea

March 22, 2019

On Dec. 18, 2018, a large "fireball—the term used for exceptionally bright meteors that are visible over a wide area—exploded about 16 miles (26 kilometers) above the Bering Sea. The explosion unleashed an estimated 173 ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.