Non-antibiotic drugs also speed up the spread of antibiotic resistance

November 16, 2018, University of Queensland
Non–antibiotic drugs also speed up the spread of antibiotic resistance
From left: Dr Jianhua Guo and PhD student Yue Wang in the lab. Credit: University of Queensland

New research from The University of Queensland has found non-antibiotic pharmaceuticals can significantly promote the spread of antibiotic resistance via bacterial mating.

A study led by Dr Jianhua Guo from UQ's Advanced Water Management Centre said while were known to promote antibiotic resistance, it wasn't known if non-antibiotic pharmaceuticals could also increase bacterial conjugation.

"Bacterial conjugation is the exchange of genetic material between by direct cell-to-cell contact or by a bridge-like connection between two cells," he said.

"It's believed bacterial conjugation, or bacterial mating, is one of the major pathways to the spread of antibiotic-resistant genes.

"Recently, we started wondering if non-antibiotic pharmaceuticals such as carbamazepine – a prescription drug used to treat epilepsy and neuropathic pain – can accelerate the transmission of antibiotic resistance through bacterial conjugation."

More than 1,000 tons of carbamazepine is consumed worldwide each year.

It can accumulate and remain in various environments for years because of its resistance to biodegradation.

UQ PhD student Yue Wang said the research found carbamazepine significantly enhanced the bacterial conjugation not only within the same bacterial species, but also across bacterial genera.

"This discovery provides strong evidence that carbamazepine at environmentally relevant concentrations directly promotes the transfer of multi-antibiotic resistance genes," Dr Guo said.  

"Further work is required to investigate if similar effects have been caused by carbamazepine in human gut microbiota."

The , along with previous studies by the group on triclosan and fluoxetine, is a warning to re-evaluate the potential roles of non-antibiotic pharmaceuticals in the spread of antibiotic resistance.

Antimicrobial resistance has become a major threat to globally with approximately 700,000 people a year dying from antimicrobial-resistant infections.

The finding coincides with World Antibiotic Awareness Week, which aims to increase global awareness of .

The study has been published in The ISME Journal.

Explore further: Antidepressants may cause antibiotic resistance

More information: Yue Wang et al. Antiepileptic drug carbamazepine promotes horizontal transfer of plasmid-borne multi-antibiotic resistance genes within and across bacterial genera, The ISME Journal (2018). DOI: 10.1038/s41396-018-0275-x

Related Stories

Recommended for you

60 percent of coffee varieties face 'extinction risk'

January 16, 2019

Three in five species of wild coffee are at risk of extinction as a deadly mix of climate change, disease and deforestation puts the future of the world's favourite beverage in jeopardy, new research warned Wednesday.

How stem cells self-organize in the developing embryo

January 16, 2019

Embryonic development is a process of profound physical transformation, one that has challenged researchers for centuries. How do genes and molecules control forces and tissue stiffness to orchestrate the emergence of form ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.