Ancient extinct cave bear DNA found in modern bears
An international team of researchers has found evidence of extinct cave bear DNA in modern bears. In their paper published in the journal Nature Ecology & Evolution, the group describes their genetic analysis of modern brown and polar bears and how they compared with extinct cave bears.
Cave bears were a type of bear that lived in Asia and Europe. They were slightly larger than today's brown bears, but fed on vegetation instead of meat. They went extinct approximately 24,000 years ago (during the Last Glacial Maximum) for unknown reasons. In this new effort, the research team was focused on learning why the bears went extinct. To that end, they conducted a DNA analysis on samples taken from four bear's remains from approximately 35,000 years ago. Their goal was to study how the population of cave bears changed in size over long time periods. As an aside, they decided to compare the DNA from the extinct cave bears with modern bears.
The researchers report that their comparison revealed that modern brown and polar bears both have cave bear DNA—on average 0.9 to 2.4 percent of their genome is cave bear DNA. They noted that the two types of modern bears are more genetically alike than they are to the cave bears. But they found that either was capable of mating with a cave bear, and that their offspring could breed with any of the three types, as well. They point out that their results are not surprising—the similarities between the bears, the overlapping time period in which they lived, and their habitat proximity made interbreeding a near-certainty. The finding of extinct cave bear DNA in modern bears is the first example of DNA from an ancient extinct species found in a modern species other than humans—we have remnants of Neanderthal DNA in our genomes.
The researchers suggest that future research could explore what it means for a species to go extinct—if their DNA lives on in other species, are they really, truly gone? They note that their study reaffirms the fact that animal species interbreed, some regularly. That might have been the case with modern bears and cave bears—the ancient cave bears also had modern bear DNA in their gene pools.
More information: Axel Barlow et al. Partial genomic survival of cave bears in living brown bears, Nature Ecology & Evolution (2018). DOI: 10.1038/s41559-018-0654-8
Although many large mammal species went extinct at the end of the Pleistocene epoch, their DNA may persist due to past episodes of interspecies admixture. However, direct empirical evidence of the persistence of ancient alleles remains scarce. Here, we present multifold coverage genomic data from four Late Pleistocene cave bears (Ursus spelaeus complex) and show that cave bears hybridized with brown bears (Ursus arctos) during the Pleistocene. We develop an approach to assess both the directionality and relative timing of gene flow. We find that segments of cave bear DNA still persist in the genomes of living brown bears, with cave bears contributing 0.9 to 2.4% of the genomes of all brown bears investigated. Our results show that even though extinction is typically considered as absolute, following admixture, fragments of the gene pool of extinct species can survive for tens of thousands of years in the genomes of extant recipient species.
Journal information: Nature Ecology & Evolution
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