A molecular label allows traceability for medical implants

July 6, 2018, CNRS

A team of researchers at CNRS, Aix-Marseille Université and Université Paris 13 has demonstrated effective molecular labeling to unequivocally identify biomedical implants, even after a prolonged period inside a living subject. The results were published in Angewandte Chemie International Edition on July 5, 2018.

Identification and traceability is extremely important for . Patients and doctors must be able to determine the origin of adulterated implants responsible for clinical complications. However, if the packaging is not stored, it is quite difficult to authenticate an , especially if it has been in use for several years. In this context, teams from the CNRS Institut Charles Sadron, the Laboratoire de Recherche Vasculaire Translationnelle (Université Paris 13/INSERM/Université Paris Diderot) and the Institut de Chimie Radicalaire (CNRS/Aix-Marseille Université) have recently developed an innovative solution that can chemically "label" an implant at the molecular level.

The researchers have used polymers to do this. These are large molecules composed of two basic subunits whose linking connections form a code, similar to sequences of zeroes and ones in computing. By determining the of each polymer fragment using an analytical chemistry method called , the molecule's "code" can be determined and decrypted in the same way as a bar code.

These molecular labels have been incorporated in tiny quantities in model implants, which were implanted into rats. After three months, the implants were extracted from the animals and analyzed. Mass spectrometry showed that the identification polymer could be decoded unambiguously.

These results are a major step forward for the field of traceability and preventing counterfeiting for healthcare materials. Mass spectrometry is already used in many healthcare facilities and analytical laboratories, so this identification method could easily be extended to other applications.

Explore further: World's first digitally-encoded synthetic polymers

More information: Denise Karamessini et al, Abiotic sequence-coded oligomers as efficient in vivo taggants for identification of implanted materials, Angewandte Chemie International Edition (2018). DOI: 10.1002/anie.201804895

Related Stories

World's first digitally-encoded synthetic polymers

June 5, 2015

Researchers have for the first time succeeded in recording a binary code on a synthetic polymer. Inspired by the capacity of DNA to retain an enormous amount of genetic information, a team from the Institut Charles Sadron ...

Clouds reveal new particle formation process

February 15, 2016

In addition to precipitation, clouds influence the climate in various ways: they cover 70% of the Earth's surface and represent nearly 15% of the volume of the atmosphere. Scientists need to understand their underlying chemical ...

Fish in schools can take it easy

May 9, 2018

Using a new computer model, researchers at the Ecole Centrale de Marseille and CNRS have shown that a fish expends less energy when it swims in a school, because neighbouring fish produce a 'suction' effect. This work will ...

A new gelling molecule for growing neurons in 3-D

May 15, 2018

A multidisciplinary team of researchers from CNRS, INSERM and Université Toulouse III – Paul Sabatier has developed a hydrogel that can grow, develop and differentiate neural stem cells. This biomaterial could provide ...

Light-controlled gearbox for nanomachines

March 21, 2017

Rewarded with a Nobel Prize in Chemistry in 2016, nanomachines provide mechanical work on the smallest of scales. Yet at such small dimensions, molecular motors can complete this work in only one direction. Researchers from ...

Recommended for you

Seeing small-molecule interactions inside cells

December 12, 2018

Like people in a large company, proteins in cells constantly interact with each other to perform various jobs. To develop new disease therapies, researchers are trying to control these interactions with small-molecule drugs ...

The stiffest porous lightweight materials ever

December 12, 2018

Researchers at ETH have developed and manufactured a family of architectures that maximises the stiffness of porous lightweight materials. It's practically impossible to develop stiffer designs.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.