Plaster which sticks inside the mouth could improve treatment of oral conditions

June 25, 2018, University of Sheffield
The biodegradable patch sticks inside the mouth and helps to accelerate the treatment of painful ulcers Credit: University of Sheffield

A plaster which sticks to the inside of your mouth is revolutionising the treatment of painful recurring ulcers.

Scientists from the University of Sheffield's School of Clinical Dentistry, working in close collaboration with Dermtreat A/S from Copenhagen, have developed a unique using special polymers which are able to stick to moist surfaces.

The patch successfully administers steroids directly to oral ulcers or lesions whilst also creating a protective barrier around the affected area, accelerating the healing process.

The novel plaster is a breakthrough therapy for the treatment of mucosal conditions such as oral lichen planus (OLP) and (RAS), which are diseases that cause painful lesions and affect 1-2 per cent of the population.

Until now, ulcers and lesions inside the mouth have been treated using either creams or mouthwashes, which are used in the whole mouth rather than targeting the specific area, making them less effective. However, the biodegradable Rivelin patch, has a long adhesion time and a high flexibility which conforms to the surface inside the mouth.

Dr. Craig Murdoch, Reader in Oral Bioscience School of Clinical Dentistry and lead author of the research, said: "Chronic inflammatory conditions such as OLP and RAS, which cause erosive and painful oral , have a considerable impact on quality of life.

"Current treatments consist of using steroids in the form of mouthwashes, creams or ointments, but these are often ineffective due to inadequate drug contact times with the lesion.

"The patch acts like a plaster inside your , which means it is very effective at directly targeting the specific area as well as forming a protective barrier.

"Patients who have trialled the patch found it to be very comfortable to wear and they were really pleased with the length of adhesion which makes it particularly effective and efficient."

Jens Hansen, Chief Executive Officer at Dermtreat A/S, added: "Collaboration with the University of Sheffield has undoubtedly accelerated the translation of our intellectual property towards clinical use. Our company are very confident that we will soon gain regulatory approval for the first adhesive drug delivery technology to address pressing clinical needs in oral medicine.

"We look forward to continuing this collaboration, which will be increasingly directed at finding new clinical applications for muco-adhesive patches."

Dermtreat A/S was recently awarded $17.7 million from the venture capital firm Sofinnova. The funding will take the patches into phase two clinical trials, which will run at several sites in both the US and the UK—including at the Charles Clifford Dental Hospital in Sheffield. In addition, Dermtreat are funding further research at the Dental School to develop the next generation of patches that contain other useful drugs.

The findings of the research are published in the journal Biomaterials.

Explore further: Dry mouth problems may be associated with disease in the eyelids

More information: H.E. Colley et al, Pre-clinical evaluation of novel mucoadhesive bilayer patches for local delivery of clobetasol-17-propionate to the oral mucosa, Biomaterials (2018). DOI: 10.1016/j.biomaterials.2018.06.009

Related Stories

Researchers bring oral cancer-fighting patch to patients

June 6, 2014

(Medical Xpress)—The Ohio State University and the University of Michigan have signed an exclusive worldwide agreement with Ohio-based Venture Therapeutics, Inc, to form a new company to develop and commercialize a pharmaceutical ...

Development of drugs for local treatment of oral conditions

June 23, 2016

On June 24, 2016, at the 94th General Session & Exhibition of the International Association for Dental Research, researcher W. Peter Holbrook, University of Iceland, will present a study titled "Development of Drugs for Local ...

Recommended for you

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.