New method helps make orthotopic brain-tumor imaging clearer and faster

June 11, 2018, Chinese Academy of Sciences
New method helps make orthotopic brain-tumor imaging clearer and faster
NIR-II fluorescent molecule with aggregation-induced-emission (AIE) used for orthotopic brain-tumor imaging. Credit: ZHENG Hairong

Currently, tumors inside the central nervous system are among the most challenging cancers to diagnose. Different from conventional brain-imaging techniques, near-infrared fluorescence imaging (NIR) demonstrates particular merits including being nonhazardous, offering fast feedback, and having higher sensitivity.

A research team led by Prof. ZHENG Hairong from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences, in collaboration with Prof. LIU Bin from the University of Singapore, reported the first NIR-II fluorescent molecule with aggregation-induced-emission (AIE) characteristics for dual fluorescence and photoacoustic imaging. Their findings were published in Advanced Materials.

Fluorescence imaging in the second NIR window (NIR-II), compared with the first NIR window (NIR-I), exhibits salient advantages of deeper penetration and higher spatiotemporal resolution, owing to further reduced photon scattering, absorption, and tissue autofluorescence in biological tissues. Scientists have designed a new donor-acceptor (D-A)-tailored NIR-II emissive AIE molecule, and formulated dots showed a high NIR-II fluorescence quantum yield up to 6.2 percent, owing to the intrinsic aggregation-induced emission nature of the designed molecule.

The AIE dots have been successfully used for dual NIR-II fluorescence and NIR-I photoacoustic imaging for precise noninvasive brain-tumor diagnosis. Based on the same dots, the experiments revealed that NIR-II showed a high resolution.

Meanwhile, NIR-I PA imaging intrinsically exhibited higher penetration depth than that of NIR-II fluorescence imaging, which allowed clear delineation of tumor depth in the brain.

The synergetic bimodal imaging with targeting c-RGD-decorated bright AIE nanoparticles showed precise brain-tumor diagnosis with good specificity and high sensitivity, which yielded a high S/B of 4.4 and accurately assessed the depth of tumor location inside brain tissue.

The study demonstrates the promise of NIR-II AIE molecules and their dots in dual NIR-II and NIR-I photoacoustic imaging for precise brain cancer diagnostics.

Explore further: SPECT/CT combined with fluorescence imaging detects micrometastases

More information: Zonghai Sheng et al, Bright Aggregation-Induced-Emission Dots for Targeted Synergetic NIR-II Fluorescence and NIR-I Photoacoustic Imaging of Orthotopic Brain Tumors, Advanced Materials (2018). DOI: 10.1002/adma.201800766

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