Treating koalas for chlamydia alters gut microbes

March 26, 2018 by Andy Fell, UC Davis
Treating koalas for chlamydia alters gut microbes
Koalas feed almost exclusively on eucalyptus leaves. They depend on gut bacteria to make the leaves digestible. (Photo via Tourism Australia)

Koalas are one of Australia's iconic animals, but they have been hard hit by an epidemic of Chlamydia infections contributing to a steep decline in numbers. Sick koalas brought to wildlife hospitals may be treated with antibiotics to clear up the chlamydia, but the antibiotics themselves can have severe side effects in the animals.

A new study led by Katherine Dahlhausen, a graduate student at the UC Davis Genome Center, published in the journal PeerJ, shows that those antibiotics may be changing the balance of thought to allow koalas to digest eucalyptus leaves.

Koalas rely on specialized gut microbes to break down tannins and other toxic compounds that would otherwise make eucalyptus leaves indigestible. Infant koalas pick up these microbes from their mothers by eating a specialized type of feces called "pap."

Dahlhausen and colleagues studied the diversity of microbes in koalas treated or not treated with antibiotics at the Australia Zoo Wildlife Hospital, Queensland and the Port Macquarie Koala Hospital, New South Wales. They did not find a difference in gut microbes between treated and untreated animals, but did find that koalas that were treated with and survived had a more diverse microbe population than animals that died during treatment.

Health status was closely correlated with presence of bacteria related to Lonepinella koalarum, a microbe known to digest tannins.

There have been other studies showing that antibiotic treatment can disturb gut microbes in other species, Dahlhausen and colleagues noted in the paper. But this might be especially important in animals like koalas where gut microbes are essential to their survival.

The project highlights the possible need to restore a healthy balance of in antibiotic treated and for development of antibiotic-free treatments of koala chlamydia infections, such as as a koala chlamydia vaccine, under development by Peter Timms' lab at the University of the Sunshine Coast, Dahlhausen said.

Explore further: Lab discovery a breakthrough for koalas infected with chlamydia

More information: Katherine E. Dahlhausen et al, Characterization of shifts of koala (Phascolarctos cinereus) intestinal microbial communities associated with antibiotic treatment, PeerJ (2018). DOI: 10.7717/peerj.4452

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