Researchers use fluorescent carbon nanotube probes to detect ovarian cancer

November 30, 2017
Rice University and MD Anderson researchers have developed a technique that uses fluorescent nanotube-based probes to locate specific tumors in the body. Credit: Weisman Lab/Rice University

Researchers at Rice University and the University of Texas MD Anderson Cancer Center have refined and, for the first time, run in vivo tests of a method that may allow nanotube-based probes to locate specific tumors in the body. Their ability to pinpoint tumors with submillimeter accuracy could eventually improve early detection and treatment of ovarian cancer.

The noninvasive technique relies on that can be optically triggered to emit shortwave infrared light. The Rice lab of chemist Bruce Weisman, a pioneer in the discovery and interpretation of the phenomenon, reported the new results in the American Chemical Society journal ACS Applied Materials and Interfaces.

For this study, the researchers used the technique to pinpoint small concentrations of nanotubes inside rodents. The lab of co-author Dr. Robert Bast Jr., an expert in and vice president for translational research at MD Anderson, inserted gel-bound carbon nanotubes into the ovaries of rodents to mimic the accumulations that are expected for nanotubes linked to special antibodies that recognize tumor cells. The rodents were then scanned with the Rice lab's custom-built optical device to detect the faint emission signatures of as little as 100 picograms of nanotubes.

The device irradiated the rodents with intense red light from an array of light-emitting diodes and read fluorescent signals with a specialized sensitive detector. Because different types of tissue absorb emissions from the nanotubes differently, the scanner took readings from many locations to triangulate the tumor's exact location, as confirmed by later MRI scans.

Weisman said it should be possible to noninvasively find small ovarian tumors within rodents used for medical research by linking to antibody biomarkers and administering the biomarkers intravenously. The biomarkers would accumulate at the tumor site. He said more refined versions of the optical scanner may then be able to locate a within seconds, and further advances may extend the method's application to human cancer detection. The new results suggested that antibody-nanotube probes could potentially detect tumors with as few as 100 , which could make it a valuable tool for .

Explore further: Nanotubes are beacons in cancer-imaging technique

More information: Ching-Wei Lin et al, In Vivo Optical Detection and Spectral Triangulation of Carbon Nanotubes, ACS Applied Materials & Interfaces (2017). DOI: 10.1021/acsami.7b12916

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