Combining pulsed laser with electron gun allows for capturing fast motion of nanoparticles in a liquid

February 3, 2017 by Bob Yirka report
Liquid cell 4D EM. Credit: (c) Science (2017). DOI: 10.1126/science.aah3582

(Phys.org)—A team of researchers at the California Institute of Technology has combined a pulsed laser with an electron gun to capture imagery of suspended nanoparticles moving at nanosecond speeds. In their paper published in the journal Science, the group describes their approach and how they used their apparatus to follow the motion of laser-excited nanoparticles. Peter Baum with Ludwig-Maximilians-Universität offers a Perspective piece on the work in the same journal issue, outlining what they have achieved and describing possible applications for their technique—he also offers some ideas on how it might be improved.

To get a better look at the building blocks of matter, scientists have aggressively pursued better microscopes that allow not just a closer look at things, but short peeks into interactions or reactions that occur at incredibly fast speeds. In this new effort, the researchers sought to combine technologies to capture ultra-fast laser pulses striking a pair of bonded gold suspended in a water solvent.

To capture the action, the researchers placed the gold nanoparticle pair in a drop of water, and then squashed the result between plates of silicon nitride, which had been chosen because it allows electrons to pass through but is strong enough to withstand the vacuum pressure inside of an . The team then aimed a laser at the nanoparticles and fired a sequence of very rapid pulses at it, causing the water to boil just next to it, exciting the nanoparticles into movement. At the same time, an fired electrons at the same , creating a flash for image capture. To create the image, the team followed a three-step process: selecting the image using quasi-continuous electron illumination, applying a laser pulse while also applying a probe pulse, and then imaging the end result once again using quasi-continuous electron illumination. By continuously repeating their three-step process, the team was able to gather a data stream of information on the changing position of the nanoparticle pair, which, when combined, comprised a video of sorts depicting the movements of the nanoparticle pair.

The technique needs refinement, as Baum notes, but opens the door to the possibility of creating microscopes to image biological interactions that occur at nanosecond speeds.

Explore further: High-energy electrons synced to ultrafast laser pulse to probe how vibrational states of atoms change in time

More information: Xuewen Fu et al. Imaging rotational dynamics of nanoparticles in liquid by 4D electron microscopy, Science (2017). DOI: 10.1126/science.aah3582

Abstract
In real time and space, four-dimensional electron microscopy (4D EM) has enabled observation of transient structures and morphologies of inorganic and organic materials. We have extended 4D EM to include liquid cells without the time resolution being limited by the response of the detector. Our approach permits the imaging of the motion and morphological dynamics of a single, same particle on nanometer and ultrashort time scales. As a first application, we studied the rotational dynamics of gold nanoparticles in aqueous solution. A full transition from the conventional diffusive rotation to superdiffusive rotation and further to a ballistic rotation was observed with increasing asymmetry of the nanoparticle morphology. We explored the underlying physics both experimentally and theoretically according to the morphological asymmetry of the nanoparticles.

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