Scientists develop vaccine against fatal prescription opioid overdose

November 23, 2016, The Scripps Research Institute
Kim Janda, Ely R. Callaway Jr. Professor of Chemistry and member of the Skaggs Institute for Chemical Biology, led the study at The Scripps Research Institute. (Photo by John Dole.) Credit: The Scripps Research Institute

Scientists at The Scripps Research Institute (TSRI) have developed a vaccine that blocks the pain-numbing effects of the opioid drugs oxycodone (oxy) and hydrocodone (hydro) in animal models. The vaccine also appears to decrease the risk of fatal opioid overdose, a growing cause of death in the United States.

"We saw both blunting of the drug's effects and, remarkably, prevention of drug lethality," said Kim D. Janda, the Ely R. Callaway Jr. Professor of Chemistry and member of the Skaggs Institute for Chemical Biology at TSRI. "The protection against overdose death was unforeseen but clearly of enormous potential clinical benefit."

The study was published this week online ahead of print in the journal ACS Chemical Biology.

How It Works

The new oxy/hydro vaccine takes advantage of the immune system's ability to recognize, seek out and neutralize invaders.

Opioids were designed to reach receptors in the brain, causing pain reduction and feelings of euphoria. For their vaccine, the researchers combined a signature opioid structure with a molecule to trigger an immune response. When injected, the vaccine teaches the immune system to bind to the drug molecule and remove it from circulation.

The vaccine-derived antibodies were tailored by TSRI scientists to seek out the prescription drug and block the opioid from reaching the brain, potentially depriving a person of the "reward" of consuming the drug, Janda explained.

The scientists believe a could have an advantage over current opioid addiction therapies because it would not alter brain chemistry like many of today's anti-addiction therapies do.

"The vaccine approach stops the drug before it even gets to the brain," said study co-author Cody J. Wenthur, a research associate in the Janda laboratory. "It's like a preemptive strike."

Lab Tests Show Promise

The researchers found that their blocked pain perception of oxy/hydro use in mice. Indeed, those given the vaccine did not display the usual symptoms of a drug high, such as ignoring pain and discomfort.

In further tests, the rodents also appeared less susceptible to fatal overdose. Although it was found that some vaccinated mice did succumb to the 's toxic effects, the researchers noted that it took much longer for the drug to impart its toxicity. If this effect holds true in humans, the vaccine could extend the window of time for clinical assistance if overdose occurs.

The scientists also discovered that the vaccine remained effective in mice for the entire 60-day study period, and they believe it has the potential to last even longer.

This oxy/hydro vaccine is not the first ever tested, but it is the first to use a faithful representation of the opioid in its design, which prompts the remarkable efficacy seen with the TSRI vaccine. "Our goal was to create a vaccine that mirrored the drug's natural structure. Clearly this tactic provided a broadly useful opioid deterrent," said study first author Atsushi Kimishima, a research associate in the Janda laboratory.

The study did raise some new questions. For example, researchers found that once antibodies bound to the drug, the stayed in the body—though neutralized—for a long time. The next steps will be to investigate this phenomenon and further study the optimal vaccine dose and injection schedule. The scientists also stated it may be possible to make the even more effective.

Explore further: Scientists create vaccine against dangerous designer opioids

More information: "An Advance in Prescription Opioid Vaccines: Overdose Mortality Reduction and Extraordinary Alteration of Drug Half-Life," ACS Chemical Biology, 2016.

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3 / 5 (2) Nov 23, 2016
Very interesting, but it seems shortsighted. OK, you are addicted to opioids for whatever reason and this vaccine 'cures' you. Life it good, until you get in a horrible accident and need powerful pain killers. if we haven't developed good alternative pain killers by then you are royally screwed?? Now, if there is some way to reverse the immunity, then you've really got something. Or if the immunity fades over a matter of months, that might be enough to get unhooked without the long term danger of losing powerful pain relief.
2 / 5 (1) Nov 23, 2016
What an incredibly ignorant article.

Chemical agents that block opiates have been around for 50 years or more. See Naloxone. This is a press release written by a pharmaceutical company.
4 / 5 (1) Nov 24, 2016
Naloxone lasts for a half an hour. Learn to read.
2.5 / 5 (2) Nov 24, 2016
Brilliant! Two excellent painkillers rendered useless

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