First report on efficient reprogramming of diabetic foot ulcer cells to create therapeutic stem cell

First report on efficient reprogramming of diabetic foot ulcer cells to create therapeutic stem cell
Cellular Reprogramming, published bimonthly online with open access options and in print, is the premier peer-reviewed research journal on the etiology, development, and potential treatment of disease through reprogramming cellular mechanisms. Coverage includes somatic cell nuclear transfer and reprogramming in early embryos; embryonic stem cells; nuclear transfer stem cells; generation of induced pluripotent stem (iPS) cells; epigenetics; and adult stem cells and pluripotency. A complete table of content and a sample issue may be viewed on the Cellular Reprogramming website. Credit: Mary Ann Liebert, Inc., publishers

The potential to use a patient's own cells to treat non-healing chronic wounds - a serious complication of diabetes - took an important step forward as researchers successfully reprogrammed skin cells taken from diabetic foot ulcers to form induced pluripotent stem cells (iPSCs). The reprogramming technique was similar in efficiency to the results achieved using healthy foot skin from non-diabetic patients, as described in the study published in Cellular Reprogramming.

iPSCs have the potential to develop into a variety of cell types and can be used to create disease models to study new therapeutic approaches, such as activating regenerative capabilities that could convert non-healing fibroblasts into that regain their repair functions.

In the article "Generation of Induced Pluripotent Stem Cells From Diabetic Foot Ulcer Fibroblasts Using a Nonintegrative Sendai Virus", Behzad Gerami-Naini, PhD and coauthors from the School of Dental Medicine and the Sackler School of Graduate Biomedical Sciences, Tufts University (Boston, MA), and Beth Israel Deaconess Medical Center and the School of Engineering and Applied Sciences, Harvard University (Boston and Cambridge, MA), present a technique that uses a non-integrating Sendai virus to reprogram fibroblast cell lines. The researchers describe the future therapeutic potential of reprogrammed diabetic foot ulcer-derived cells, which could undergo epigenetic remodeling, a change that may reverse disease processes

"This research has created two new approaches to the study and treatment of . It has revealed an important new source of cells for treatment of such ulcers," says Professor Sir Ian Wilmut, OBE, FRS, FRSE, Editor-In-Chief of Cellular Reprogramming and Emeritus Professor in the MRC Centre for Regenerative Medicine, Scottish Centre for Regenerative Medicine, University of Edinburgh (UK). "In addition, research on "reprogrammed cells" from such ulcers may reveal the molecular changes that caused the ulcers."


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Non-healing tissue from diabetic foot ulcers reprogrammed as pluripotent stem cells

More information: Behzad Gerami-Naini et al, Generation of Induced Pluripotent Stem Cells from Diabetic Foot Ulcer Fibroblasts Using a Nonintegrative Sendai Virus, Cellular Reprogramming (2016). DOI: 10.1089/cell.2015.0087
Citation: First report on efficient reprogramming of diabetic foot ulcer cells to create therapeutic stem cell (2016, August 10) retrieved 21 April 2021 from https://phys.org/news/2016-08-efficient-reprogramming-diabetic-foot-ulcer.html
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