Researchers describe how free radicals contribute to aging

Researchers describe how free radicals contribute to aging
Credit: Yale University

Aging in part is the result of oxidative damage to proteins caused by free radicals, a byproduct of interaction of our bodies and radiation such as sunlight. A new study by Yale scientists provides some clues into how this damage is inflicted.

The research team headed by Jimin Wang analyzed protein structures after bombardment with massive amount of X-rays.

They found many different examples of added to the proteins and polypeptide bonds within proteins, rendering them non-functional.

Some of these damaged proteins also become unrecognizable to proteasomes, the cellular garbage collectors that clean up faulty proteins.

The problems are compounded because proteasomes themselves are also damaged while trying to clean faulty proteins.

This further limits the process of cellular cleanup, a failure that is a major characteristic of aging.

The work is described in this week issue of the journal Protein Science.


Explore further

Halting protein degradation may contribute to new cancer treatment

More information: Jimin Wang. X-ray radiation-induced addition of oxygen atoms to protein residues, Protein Science (2016). DOI: 10.1002/pro.2934
Provided by Yale University
Citation: Researchers describe how free radicals contribute to aging (2016, July 22) retrieved 10 August 2020 from https://phys.org/news/2016-07-free-radicals-contribute-aging.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
6 shares

Feedback to editors

User comments